Preparation of TPP-crosslinked chitosan microparticles by spray drying for the controlled delivery of progesterone intended for estrus synchronization in cattle

Pharmaceutical Research
Ignacio M HelblingJulio A Luna

Abstract

Planned reproduction in cattle involves regulation of estrous cycle and the use of artificial insemination. Cycle control includes the administration of exogenous progesterone during 5-8 days in a controlled manner allowing females to synchronize their ovulation. Several progesterone delivery systems are commercially available but they have several drawbacks. The aim of the present contribution was to evaluate chitosan microparticles entrapping progesterone as an alternative system. Microparticles were prepared by spray drying. The effect of formulation parameters and experimental conditions on particle features and delivery was studied. A mathematical model to predict progesterone plasma concentration in animals was developed and validated with experimental data. Microparticle size was not affected by formulation parameters but sphericity enhances as Tween 80 content increases and it impairs as TPP content rises. Z potential decreases as phosphate content rises. Particles remain stable in acidic solution but the addition of surfactant is required to stabilize dispersions in neutral medium. Encapsulation efficiencies was 69-75%. In vitro delivery studies showed burst and diffusion-controlled phases, being progesterone released ...Continue Reading

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Citations

Oct 24, 2018·Materials·Alecsandra Ferreira TomazMarcus Vinícius L Fook
May 18, 2020·Animals : an Open Access Journal From MDPI·Nesrein M Hashem, Antonio Gonzalez-Bulnes
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rodolpho Fagundes CorreaMaria Filomena Barreiro
Sep 5, 2018·Carbohydrate Polymers·Sergio Martin-SaldañaAlberto Antonio Chevalier
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Nesrein M Hashem, Antonio Gonzalez-Bulnes

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Methods Mentioned

BETA
Size Exclusion Chromatography
scanning electron microscopy
Infrared Spectroscopy

Software Mentioned

MatLab®

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