PMID: 11330478May 2, 2001Paper

Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of

Journal of Inorganic Biochemistry
Zdenek TrávnícekJ Marek

Abstract

Copper(II) complexes of 6-(2-chlorobenzylamino)purine (HL1) and 6-(3-chlorobenzylamino)purine (HL2), respectively, were prepared. Depending on the pH of the medium and the molar ratio of reactants the following mononuclear (trigonal-bipyramidal) and dinuclear (octahedral, trigonal-bipyramidal or tetrahedral) complexes were isolated: [Cu2(mu-HL1)2(mu-Cl2)2(HL1)2Cl2] (1a,b), [Cu2(mu-Cl)2(mu-L1)2(H2O)2] (2a), [Cu2(mu-Cl)2(mu-L2)2(H2O)2] (2b), [Cu(H+L2)2Cl3]Cl.H2O (3a,b), [Cu2(mu-Cl)2(HL1)2Cl2] (4a), and [Cu2(mu-Cl)2(HL2)2Cl2] (4b). The compounds were characterized by elemental analyses, electronic, infrared and mass (FAB+, ES+) spectral data, magnetic susceptibility temperature dependence measurements and molar conductivity data. An X-ray single-crystal structural analysis of [Cu(H+L2)2Cl3]Cl.2H2O (3b) showed that the Cu2+ ion is penta-coordinated by three chloride ions and by two H+L2 ligands. Thus, the Cu2+ ion adopts a distorted trigonal bipyramidal coordination geometry with the protonated H+L2 ligands coordinated in trans apical positions, while the three chloride ions are situated in an equatorial plane. The cytotoxic activity of the complexes was determined by a calcein AM assay. Mouse melanoma cell line B16-FO, human malig...Continue Reading

Citations

Nov 18, 2011·Molecular Biology International·Isidoros IakovidisStylianos M Piperakis
Aug 18, 2012·Bioinorganic Chemistry and Applications·Nahid ShahabadiSaba Hadidi
May 15, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eva GalanteErik Arstad
Sep 12, 2012·Bioinorganic Chemistry and Applications·Radka NovotnáRadovan Herchel
Jan 11, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Chew Hee NgMakoto Chikira
Nov 25, 2017·International Journal of Peptide Research and Therapeutics·Aleksandra KotyniaJustyna Brasuń

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