Preparation, stability and cytocompatibility of magnetic/PLA-PEG hybrids

Nanoscale
Aristides BakandritsosKonstantinos Avgoustakis

Abstract

Hybrid nanocolloids based on biodegradable polymers of poly(lactide) (PLA) or poly(lactide)-block-poly(ethylene glycol) (PLA-PEG) and hydrophobic iron oxide magnetic nanoparticles (MNPs) of ca. 5 nm are prepared via a self-assembly route. The magnetic nanoparticles are organized in superclusters inside the hydrophobic core of PLA-PEG micelles or cholate-stabilized PLA nanospheres. The hydrodynamic diameter of MNPs-loaded PLA nanospheres is approximately 250 nm, whereas that of MNPs-loaded PLA-PEG micelles is much lower (approximately 100 nm) and thus compatible with applications where prolonged blood circulation is required. The PLA-PEG micelles exhibit high encapsulation efficiency for the MNPs, imparting a saturation magnetization value to the hybrid of 8.4 emu g(-1). Both hybrid colloids display magnetic properties of a non-interacting assembly of superparamagnetic particles and a low blocking temperature, both of which are key attributes for colloidally stable ferrofluids. Furthermore, the PLA-PEG magnetic hybrids display remarkable colloidal stability at high ionic strength, temperature and in human blood plasma, while the estimated critical micelle concentration of ca. 2 x 10(-5) mM (0.3 mg L(-1)) indicates the low probab...Continue Reading

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Citations

Nov 15, 2012·Nanomedicine·George MattheolabakisPanayiotis P Constantinides
Jan 18, 2013·Therapeutic Delivery·Aristides BakandritsosDimitrios G Fatouros
Apr 25, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Zacharoula IatridiGeorgios Bokias
Jan 14, 2012·Advanced Drug Delivery Reviews·Somesree GhoshMitraSantaneel Ghosh
Jun 10, 2015·Chemical Society Reviews·Thomas L MooreAlke Petri-Fink
Mar 31, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A AngelopoulouK Avgoustakis
May 20, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Melita MenelaouGeorgios Bokias
May 3, 2014·Advanced Drug Delivery Reviews·Kevin M BennettIchio Aoki
Nov 4, 2016·Cell Proliferation·Na FuYunfeng Lin
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Ingrid Morgana Fernandes GonçalvesLúcio Roberto Cançado Castellano

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