Preparations and spectroscopic studies of organotin complexes of diclofenac

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Nikolaos KourkoumelisAlice Moukarika

Abstract

The reactions of the potent and widely used anti-inflammatory drug diclofenac, HL, with diorganotin(IV) oxides were studied. The dimeric tetraorganodistannoxane complexes [Me(2)LSnOSnLMe(2)](2), [Bu(2)LSnOSnLBu(2)](2), [Ph(2)LSnOSnLPh(2)](2) and the dibutyltin complex [Bu(2)SnL(2)], have been prepared and structurally characterized in the solid state by means of vibrational and 119Sn Mössbauer spectroscopy. Determination of lattice dynamics by temperature-dependent 119Sn Mössbauer spectroscopy. From the variable-temperature Mössbauer effect, the Debye temperature was determined. The complexes have been characterized in solution by NMR (1H and 13C) spectroscopy. Vibrational, Mössbauer, and NMR data are discussed in terms of the proposed structures.

References

Sep 1, 1990·Journal of Medicinal Chemistry·P MoserI Wiesenberg
Apr 28, 1986·The American Journal of Medicine·A R Sallmann
Jun 1, 2000·Journal of Inorganic Biochemistry·D Kovala-Demertzi

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Citations

Oct 18, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Sevim Hamamci Alisir, Necmi Dege
Dec 6, 2016·Acta Crystallographica. Section C, Structural Chemistry·Sevim Hamamci Alisir, Necmi Dege
Nov 16, 2018·Journal of Biochemical and Molecular Toxicology·Akif Evren ParlakMustafa Karatepe
Jul 30, 2018·Journal of Inorganic Biochemistry·Santosh KumarGeorge Psomas

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