Preparative purification of tyrosinamide N-linked oligosaccharides

Journal of Chromatography. a
K G Rice, M L Corradi da Silva

Abstract

N-linked oligosaccharides from glycoproteins can be either analyzed on a sub-nanomole scale or preparatively purified on a multi-micromole scale. Each goal necessitates a unique analytical strategy often involving oligosaccharide derivatization to enhance separation and detection. Tyrosinamide-oligosaccharides were developed to facilitate the preparative purification of N-linked oligosaccharides. These have found many uses in oligosaccharide remodeling, in the preparation of neoglycoconjugates, in developing receptor probes, and even as analytical standards in chromatography. This review discusses progress in the preparation of tyrosinamide-oligosaccharides from different glycoproteins and their utility in glycobiology research.

References

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Citations

Jul 19, 2006·Chembiochem : a European Journal of Chemical Biology·Christian PlathThomas Peters

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