Preparing for safety monitoring after rotavirus vaccine implementation: a retrospective review of intussusception cases among children at a large teaching hospital in Rwanda, 2009-2012

The Pediatric Infectious Disease Journal
Edouard NgendahayoFidele Ngabo

Abstract

In some settings, rotavirus vaccines have been associated with a small risk of intussusception. This study describes the demographics, clinical characteristics and outcomes of children with intussusception in Rwanda before vaccine introduction in May 2012. We retrospectively reviewed data on pediatric patients treated for intussusception at University Teaching Hospital of Kigali from January 2009 to June 2012. Hospital registries were reviewed to identify intussusception cases. Archived patient files were abstracted to collect data on demographics, clinical presentation, surgery and outcome. During the study period, 70 children ≤19 years of age were treated for intussusception and patient files were retrieved for 60 (86%) cases. Over half of patients (58%) were <1 year of age and 90% were transferred from a district hospital. Only 30% of patients presented within 3 days of symptom onset and 35% experienced a delay of ≥6 hours between surgical review and surgery. Surgical complications were experienced by 35% of children. Over 1 quarter (28%) of children died. Compared with children who survived, children who died were significantly more likely to have experienced complications (21% vs. 71%; P < 0.001) and to be female (28% vs. ...Continue Reading

References

Oct 3, 2006·The Journal of Pediatrics·Julie E BinesUNKNOWN Intussusception Study Group
Aug 8, 2009·African Journal of Paediatric Surgery : AJPS·L O Abdur-RahmanT Odi
Apr 27, 2010·Annals of African Medicine·Sebastian O EkenzeObinna R Okwesili
Aug 13, 2010·The Journal of Infectious Diseases·S W MooreG P Hadley
Apr 12, 2011·African Journal of Paediatric Surgery : AJPS·S O Ekenze, S O Mgbor
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Dec 20, 2011·The British Journal of Surgery·L SamadB Taylor
Feb 10, 2012·JAMA : the Journal of the American Medical Association·Irene M ShuiEric Weintraub

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