Preparing Muscles for Diving: Age-Related Changes in Muscle Metabolic Profiles in Harp (Pagophilus groenlandicus) and Hooded (Cystophora cristata) Seals

Physiological and Biochemical Zoology : PBZ
Jennifer M BurnsMike O Hammill

Abstract

In adult marine mammals, muscles can sustain aerobic metabolism during dives in part because they contain large oxygen (O2) stores and metabolic rates are low. However, young pups have significantly lower tissue O2 stores and much higher mass-specific metabolic rates. To investigate how these differences may influence muscle function during dives, we measured the activities of enzymes involved in aerobic and anaerobic metabolic pathways (citrate synthase [CS], β-hydroxyacyl-coenzyme A dehydrogenase [HOAD], lactate dehydrogenase [LDH]) and the LDH isoform profile in six muscles from 41 harp (Pagophilus groenlandicus) and 30 hooded (Cystophora cristata) seals ranging in age from fetal to adult. All neonatal muscles had significantly higher absolute but lower metabolically scaled CS and HOAD activities than adults (∼ 70% and ∼ 85% lower, respectively). Developmental increases in LDH activity lagged that of aerobic enzymes and were not accompanied by changes in isozyme profile, suggesting that changes in enzyme concentration rather than structure determine activity levels. Biochemical maturation proceeded faster in the major locomotory muscles. In combination, findings suggest that pup muscles are unable to support strenuous aerobi...Continue Reading

References

Apr 25, 1977·Biochemical and Biophysical Research Communications·P S Guy, D H Snow
Sep 7, 1986·Journal of Theoretical Biology·D M LavigneK M Kovacs
Aug 1, 1967·Analytical Biochemistry·A A Dietz, T Lubrano
Sep 1, 1981·Respiration Physiology·B Emmett, P W Hochachka
Nov 1, 1980·Journal of Mammalogy·R E Stewart, D M Lavigne
Sep 1, 1994·Mechanisms of Ageing and Development·V A LupaR S Mazzeo
Feb 1, 1997·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·C LydersenM O Hammill
Apr 29, 1998·Annual Review of Physiology·G L Kooyman, P J Ponganis
Apr 12, 2000·Acta Physiologica Scandinavica·H Hoppeler, E R Weibel
Aug 11, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S R Noren, T M Williams
Apr 17, 2001·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·S R NorenJ L Dearolf
Dec 18, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·John P MattsonMichael D Delp
Apr 12, 2003·Journal of Cellular Biochemistry·Fabrice RossignolEric Clottes
Aug 4, 2004·Respiratory Physiology & Neurobiology·Patrick J Butler
Aug 18, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Randall W DavisShane B Kanatous
Oct 9, 2004·The Journal of Experimental Biology·Jennifer L LapierreMichael O Hammill
Nov 19, 2004·Journal of Muscle Research and Cell Motility·Florence GondretJean-François Hocquette
Feb 11, 2005·Physiological and Biochemical Zoology : PBZ·Danielle K GreavesJennifer M Burns
Jun 1, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Warren W Burggren
Jan 7, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L K PolasekR W Davis
Mar 4, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Julie P RichmondLorrie D Rea
Jul 4, 2006·Molecular Phylogenetics and Evolution·Ulfur ArnasonRisto Väinölä
Mar 29, 2007·Physiological and Biochemical Zoology : PBZ·Russell E SheaRobert E Ricklefs
Jun 15, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Dominique Singer, Christian Mühlfeld
Jun 20, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·J M BurnsA S Blix
Nov 13, 2007·BMC Evolutionary Biology·Jeff W HigdonSteven H Ferguson
May 23, 2008·Ecological Applications : a Publication of the Ecological Society of America·John E Walsh
Aug 12, 2008·The Journal of Experimental Biology·S B KanatousR W Davis
Oct 9, 2008·The Journal of Experimental Biology·Paul J PonganisThomas Jue
Jul 1, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Keri C LestykJ M Burns
Oct 18, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Michelle R SheroJennifer M Burns
Jan 13, 2012·PloS One·David W JohnstonDavid M Lavigne
Jan 26, 2013·The Journal of Experimental Biology·Samuel J GeiselerLars P Folkow
Aug 5, 2014·Journal of Thermal Biology·Linnea E PearsonJennifer M Burns

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Citations

Oct 17, 2019·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Michelle R SheroJennifer M Burns
Jun 20, 2020·Integrative and Comparative Biology·Emma L WeitznerAllyson G Hindle
Aug 30, 2020·Animals : an Open Access Journal From MDPI·Dirk DannenbergerBianka Grunow

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