Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

Progress in Neurobiology
Niels Vrang, Philip Just Larsen

Abstract

The scientific understanding of preproglucagon derived peptides has provided people with type 2 diabetes with two novel classes of glucose lowering agents, the dipeptidyl peptidase IV (DPP-IV) inhibitors and GLP-1 receptor agonists. For the scientists, the novel GLP-1 agonists, and DPP-IV inhibitors have evolved as useful tools to understand the role of the preproglucagon derived peptides in normal physiology and disease. However, the overwhelming interest attracted by GLP-1 analogues as potent incretins has somewhat clouded the efforts to understand the importance of preproglucagon derived peptides in other physiological contexts. In particular, our neurobiological understanding of the preproglucagon expressing neuronal pathways in the central nervous system as well as the degree to which central GLP-1 receptors are targeted by peripherally administered GLP-1 receptor agonists is still fairly limited. The role of GLP-1 as an anorectic neurotransmitter is well recognized, but clarification of the neuronal targets and physiological basis of this response is further warranted, as is the mapping of GLP-1 sensitive neurons involved in a variety of neuroendocrine and behavioral responses. Further recent evidence points to GLP-1 as a...Continue Reading

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Citations

Jan 9, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J J Holst
Jan 10, 2012·Diabetes, Obesity & Metabolism·J JelsingL Bjerre Knudsen
Mar 30, 2012·The Journal of Endocrinology·Sara BaldassanoFlavia Mulè
Jan 21, 2012·The Review of Diabetic Studies : RDS·Cendrine Cabou, Rémy Burcelin
Sep 6, 2012·Therapeutic Delivery·Marshall Grant, Andrea Leone-Bay
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Sep 10, 2014·The Journal of Clinical Investigation·Anna SecherLotte Bjerre Knudsen
Jan 13, 2011·Current Medical Research and Opinion·Jens Juul HolstEsther Nathanson
Apr 14, 2016·Molecular Metabolism·Pernille BarkholtNiels Vrang
Feb 19, 2013·Trends in Endocrinology and Metabolism : TEM·Jens Juul Holst, Carolyn F Deacon
Aug 4, 2015·Journal of Neurochemistry·Colin K Combs
Mar 1, 2015·Molecular and Cellular Endocrinology·Darleen Sandoval, Stephanie R Sisley
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Dec 15, 2012·The Journal of Comparative Neurology·Guibao GuJoseph S Heilig
Aug 25, 2015·European Journal of Pharmacology·WeiZhen LiuChristian Hölscher
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