Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Padmam PuneetMadhav Bhatia

Abstract

Preprotachykinin-A (PPT-A) gene products substance P and neurokinin-A have been shown to play an important role in neurogenic inflammation. To investigate the role of PPT-A gene products in lung injury in sepsis, polymicrobial sepsis was induced by cecal ligation and puncture in PPT-A gene-deficient mice (PPT-A(-/-)) and the wild-type control mice (PPT-A(+/+)). PPT-A gene deletion significantly protected against mortality, delayed the onset of lethality, and improved the long-term survival following cecal ligation and puncture-induced sepsis. PPT-A(-/-) mice also had significantly attenuated inflammation and damage in the lungs. The data suggest that deletion of the PPT-A gene may have contributed to the disruption in recruitment of inflammatory cells resulting in protection against tissue damage, as in these mice the sepsis-associated increase in chemokine levels is significantly attenuated.

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Citations

Jan 20, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Min HeMadhav Bhatia
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huili ZhangMadhav Bhatia
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Selena Wei Shan SioMadhav Bhatia
Nov 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jia SunMadhav Bhatia
Feb 24, 2010·The Journal of Physiology·Fabienne BrégeonYves Jammes
Sep 29, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karen C ThomasChristopher A Reilly
Oct 7, 2009·Antioxidants & Redox Signaling·Madhav Bhatia
Feb 11, 2012·American Journal of Respiratory Cell and Molecular Biology·Madhav BhatiaSamithamby Jeyaseelan
Nov 14, 2012·British Journal of Pharmacology·Jennifer Victoria Bodkin, Elizabeth Soares Fernandes
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth S FernandesSusan D Brain
Jul 12, 2014·Critical Care Medicine·Sung YangAlex B Lentsch
Feb 22, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jianmin ChenAmrita Ahluwalia
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May 15, 2007·American Journal of Physiology. Cell Physiology·Jia SunMadhav Bhatia
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Nov 14, 2007·Journal of Leukocyte Biology·Siaw Wei NgMadhav Bhatia
Sep 21, 2007·Current Infectious Disease Reports·François Philippart, Jean-Marc Cavaillon
Jul 3, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natalie ClarkSusan D Brain

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