Prepubertal Vulvar Fibroma: Neoplasm or Physiological Condition?

Journal of Pediatric and Adolescent Gynecology
Oranite GoldratJean-Christophe Noël

Abstract

Several authors have previously reconsidered vulvar fibroma, a rare prepubertal neoplasm, as a physiological labial asymmetry of early puberty, recommending a conservative approach for all cases, although some required further clarification. A fibrous mass found in the left labium majus of a 4-year-old girl was surgically removed. Imaging confirmed a relapse after 10 months and a second surgery was performed due to extremely rapid growth. No subsequent relapse occurred after 2 years of follow-up. Diagnosis confirmed prepubertal vulvar fibroma, with positive CD34 and lack of actin, desmin, S100, and estrogen receptors. A diagnosis of prepubertal labial asymmetry should prompt careful consideration of several variables, such as age, and radiologic and histologic features, in order to differentiate between a physiological condition and a neoplasm.

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Citations

Apr 19, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·S NguyenH Montaudié
Aug 1, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Anna TessariMario Cutrone
Sep 28, 2020·Pediatric Dermatology·Lauren G YiBarbara B Wilson
Nov 5, 2021·Obstetrics and Gynecology·Stephanie ChowNichole A Tyson

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