PREPULSE INHIBITION DEFICITS ONLY IN FEMALES WITH OBSESSIVE-COMPULSIVE DISORDER

Depression and Anxiety
Shari A SteinmanH Blair Simpson

Abstract

Deficits in sensorimotor gating have been hypothesized to underlie the inability to inhibit repetitive thoughts and behaviors. To test this hypothesis, this study assessed prepulse inhibition (PPI), a measure of sensorimotor gating, across three psychiatric disorders (obsessive-compulsive disorder [OCD], social anxiety disorder [SAD], and anorexia nervosa [AN]) whose clinical presentations include repetitive thoughts and behaviors We tested acoustic PPI in unmedicated individuals with OCD (n = 45), SAD (n = 37), and AN (n = 26), and compared their results to matched healthy volunteers (n = 62). All participants completed a structured clinical interview and a clinical assessment of psychiatric symptom severity. Percent PPI was significantly diminished in females with OCD compared to healthy female volunteers (P = .039). No other differences between healthy volunteers and participants with disorders (male or female) were observed. Percent PPI was not correlated with severity of obsessions and compulsions, as measured by the Yale-Brown Obsessive Compulsive Scale. This is the first study to assess PPI in participants with SAD or AN, and the largest study to assess PPI in participants with OCD. We found PPI deficits only in females ...Continue Reading

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Citations

Apr 11, 2018·Psychological Medicine·Jess Kerr-GaffneyKate Tchanturia
May 26, 2018·Reviews in the Neurosciences·Patricia G Saletti, Carlos Tomaz
Mar 8, 2020·Molecular Psychiatry·Eric A MillerLoren M Frank
Apr 19, 2020·Hormones and Behavior·Raquell de Castro ChavesFrancisca Cléa Florenço de Sousa

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