Prepulse inhibition in fawn-hooded rats: increased sensitivity to 5-HT1A receptor stimulation

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Sally MartinMaarten van den Buuse

Abstract

Prepulse inhibition of startle is a model of sensorimotor gating, which is disrupted in alcoholism, as well as mental illnesses such as schizophrenia. The fawn-hooded (FH) rat strain has been used as an animal model of alcoholism. FH rats showed significantly lower startle amplitude than Wistar-Kyoto (WKY) rats and Sprague-Dawley (SD) rats. Increasing doses of the 5-HT(1A) receptor agonist 8-OH-DPAT caused disruption of PPI, with the effect being significantly greater in FH rats compared to WKY rats. In all strains, treatment with 0.5 mg/kg of 8-OH-DPAT significantly reduced PPI. In contrast, 0.1 mg/kg of 8-OH-DPAT caused disruption only in the FH strain. Treatment with amphetamine, apomorphine and MK-801 also significantly reduced PPI, however, there was no difference between the strains. This study shows increased sensitivity of FH rats to the disruption of PPI caused by 5-HT(1A) receptor stimulation, suggesting a link between 5-HT(1A) receptors, sensorimotor gating and aspects of the FH rat phenotype.

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Citations

Jul 6, 2005·The Australian and New Zealand Journal of Psychiatry·M van den BuuseS Kusljic
Oct 21, 2015·Animals : an Open Access Journal From MDPI·Manon W H SchaapLudo J Hellebrekers
Jun 18, 2009·Journal of Neuroscience Research·Nina K PopovaAlexander V Kulikov
Jan 22, 2005·European Journal of Pharmacology·Maarten van den Buuse, Nico Wegener
Apr 22, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patricia A Broderick, Omotola Hope
Sep 24, 2010·The International Journal of Neuropsychopharmacology·Javier A BravoJohn F Cryan

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