Prepulse inhibition (PPI) of auditory startle reflex is associated with PPI of auditory-evoked theta oscillations in healthy humans

Neuroscience Letters
Karina K KedziorC Başar-Eroglu

Abstract

The aim of the current study was to investigate the auditory-evoked theta oscillatory activity associated with prepulse inhibition (PPI) of the startle reflex in healthy humans. Concurrent electroencephalogram (EEG) and auditory startle reflex were recorded from 19 healthy controls during Pulse-Alone and Prepulse + Pulse trials with 60, 120, and 240 ms prepulse-pulse intervals. Compared to Pulse-Alone trials significant PPI of the startle reflex occurred on all Prepulse + Pulse trials and a significant startle latency reduction occurred on 60 and 120 ms Prepulse + Pulse trials. The largest evoked potentials to auditory stimuli occurred at fronto-central locations. PPI of theta oscillations occurred at frontal, central, and parietal locations. These results suggest that PPI functions not only as sensory-motor gating but also as sensory-cognitive gating since theta oscillations are involved in control of cognitive processes. Absence of significant correlations between PPI of the startle reflex and of theta oscillations at all electrode locations indicates that the two processes may be controlled by different neural mechanisms.

References

Apr 21, 1999·Brain Research. Brain Research Reviews·W Klimesch
Aug 27, 1999·Progress in Neurobiology·M Koch
Feb 7, 2001·Current Opinion in Neurobiology·G Kuperberg, S Heckers
Feb 13, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·C Başar-Eroglu, T Demiralp
Feb 13, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·E BaşarO Sakowitz
Feb 13, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·E BaşarM Schürmann
Feb 22, 2005·Psychophysiology·Terry D BlumenthalAnton van Boxtel
Apr 5, 2005·Biological Psychology·Neal R SwerdlowPamela P Auerbach
Nov 18, 2005·Brain Research. Cognitive Brain Research·C SchmiedtC Basar-Eroglu

❮ Previous
Next ❯

Citations

Jan 15, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Agnès AnnicKathy Dujardin
Sep 4, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Vilfredo De PascalisEmanuela Russo
Sep 19, 2006·Journal of Molecular Biology·Kazuhiro NakamuraSachiko Hirose
Sep 10, 2014·Behavioural Brain Research·Nathanael J YatesJennifer Rodger
Aug 16, 2016·Frontiers in Human Neuroscience·Agnès AnnicKathy Dujardin
Jan 30, 2020·European Journal of Clinical Investigation·Fotini KapsaliCharalabos Papageorgiou
Apr 30, 2020·Physiological Measurement·Georgios BalogiannisCharalabos Papageorgiou
Mar 19, 2021·Psychiatry Research·Anastasios E GiannopoulosCharalabos C Papageorgiou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.