Prepulse inhibition predicts spatial working memory performance in the inbred Roman high- and low-avoidance rats and in genetically heterogeneous NIH-HS rats: relevance for studying pre-attentive and cognitive anomalies in schizophrenia

Frontiers in Behavioral Neuroscience
Ignasi OliverasAlberto Fernández-Teruel

Abstract

Animal models of schizophrenia-relevant symptoms are increasingly important for progress in our understanding of the neurobiological basis of the disorder and for discovering novel and more specific treatments. Prepulse inhibition (PPI) and working memory, which are impaired in schizophrenic patients, are among the symptoms/processes modeled in those animal analogs. We have evaluated whether a genetically-selected rat model, the Roman high-avoidance inbred strain (RHA-I), displays PPI deficits as compared with its Roman low-avoidance (RLA-I) counterpart and the genetically heterogeneous NIH-HS rat stock. We have investigated whether PPI deficits predict spatial working memory impairments (in the Morris water maze; MWM) in these three rat types (Experiment 1), as well as in a separate sample of NIH-HS rats stratified according to their extreme (High, Medium, Low) PPI scores (Experiment 2). The results from Experiment 1 show that RHA-I rats display PPI and spatial working memory deficits compared to both RLA-I and NIH-HS rats. Likewise, in Experiment 2, "Low-PPI" NIH-HS rats present significantly impaired working memory with respect to "Medium-PPI" and "High-PPI" NIH-HS subgroups. Further support to these results comes from corre...Continue Reading

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Citations

Jun 14, 2016·Acta Psychiatrica Scandinavica·E M Sánchez-MorlaJ L Santos
Apr 16, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carles Tapias-EspinosaAlberto Fernández-Teruel
Dec 8, 2017·Journal of Molecular Neuroscience : MN·Alma Genis-MendozaSandra Morales-Mulia
Jul 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Anastasia DiamantopoulouJoseph A Gogos
Jul 18, 2017·Behavior Genetics·Cristóbal Río-ÁlamosAlberto Fernández-Teruel
Jan 25, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A Sánchez-GonzálezA Fernández-Teruel
Apr 23, 2021·Behavioural Processes·Daniel Sampedro-VianaAlberto Fernández-Teruel

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