PMID: 7516949Mar 1, 1994Paper

PreS1 deleted variants of hepatitis B virus in patients with chronic hepatitis

Journal of Hepatology
E NakajimaTakeshi Okanoue

Abstract

Defective hepatitis B virus lacking 183 bases of the 3'-terminus part of the preS1 region was found in the sera of two patients with chronic hepatitis B virus infection. Results of sequencing analysis of samples with or without polymerase chain reaction yielded the same result, proving that this deletion was not due to an artifact obtained during polymerase chain reaction. One of the deletion ends lay in TCAGG that appeared five times in the genome of subtype adr and the other end was identified as TCAGG in direct repeats of the genome. The mutated hepatitis B virus became predominant in one patient's serum only after consecutive interferon therapy, suggesting that the deleted part might play a role in viral elimination from the circulation.

References

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Citations

Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C T BockC Trautwein
Jan 1, 1997·International Journal of Clinical & Laboratory Research·H E Blum
Mar 29, 2006·Journal of Gastroenterology·Takeshi Okanoue, Masahito Minami
Mar 27, 2001·Journal of Viral Hepatitis·S Seddigh-TonekaboniP Karayiannis
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CabrerizoV Carreno
Sep 1, 1996·Nucleic Acids Research·A H Kidd, K Kidd-Ljunggren
Mar 26, 2004·Journal of Medical Virology·Bing-Fang ChenPei-Jer Chen
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C T BockC Trautwein
Jun 10, 2003·Journal of Medical Virology·Fuminaka SugauchiMasashi Mizokami
Mar 21, 2003·Pediatric Research·Patrick GernerStefan Wirth
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Q SuP Bannasch
Jan 1, 1996·Scandinavian Journal of Infectious Diseases·K Kidd-Ljunggren
Sep 28, 2016·World Journal of Gastroenterology : WJG·Bing-Fang Chen
Jun 27, 2019·Alimentary Pharmacology & Therapeutics·Bingfu JiangEberhard Hildt
Apr 18, 2018·World Journal of Gastroenterology : WJG·Bing-Fang Chen
Dec 29, 2020·AIMS Microbiology·Manoj Kumar Rajput

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