PRESAGE: PRivacy-preserving gEnetic testing via SoftwAre Guard Extension

BMC Medical Genomics
Feng ChenShuang Wang


Advances in DNA sequencing technologies have prompted a wide range of genomic applications to improve healthcare and facilitate biomedical research. However, privacy and security concerns have emerged as a challenge for utilizing cloud computing to handle sensitive genomic data. We present one of the first implementations of Software Guard Extension (SGX) based securely outsourced genetic testing framework, which leverages multiple cryptographic protocols and minimal perfect hash scheme to enable efficient and secure data storage and computation outsourcing. We compared the performance of the proposed PRESAGE framework with the state-of-the-art homomorphic encryption scheme, as well as the plaintext implementation. The experimental results demonstrated significant performance over the homomorphic encryption methods and a small computational overhead in comparison to plaintext implementation. The proposed PRESAGE provides an alternative solution for secure and efficient genomic data outsourcing in an untrusted cloud by using a hybrid framework that combines secure hardware and multiple crypto protocols.


Jul 13, 2004·Science·Zhen LinRuss B Altman
Jan 19, 2013·Science·Melissa GymrekYaniv Erlich
Aug 22, 2013·Journal of the American Medical Informatics Association : JAMIA·Richard LeDucWilliam Barnett
Mar 22, 2014·PLoS Genetics·Peter ClaesMark D Shriver
May 9, 2014·Nature Reviews. Genetics·Yaniv Erlich, Arvind Narayanan
May 20, 2014·Journal of Biomedical Informatics·Joppe W BosMichael Naehrig
Jan 31, 2015·The New England Journal of Medicine·Francis S Collins, Harold Varmus
Jul 7, 2015·IEEE International Conference on Systems Biology : [proceedings]·Feng ChenXiaoqian Jiang
Nov 3, 2015·American Journal of Human Genetics·Suyash S Shringarpure, Carlos D Bustamante
Jan 7, 2016·BMC Medical Informatics and Decision Making·Scott D ConstableSteve Chapin
Jan 7, 2016·BMC Medical Informatics and Decision Making·Yihua ZhangGhada Almashaqbeh
Jan 7, 2016·BMC Medical Informatics and Decision Making·Yuchen ZhangShuang Wang
Jan 15, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Paul J McLarenAmalio Telenti
Feb 26, 2016·Nature Methods·David W Craig
Apr 15, 2016·Journal of the American Medical Informatics Association : JAMIA·Kim M UnertlIndra Neil Sarkar
Jul 28, 2016·BMC Medical Informatics and Decision Making·Haoyi ShiShuang Wang
Sep 30, 2016·Annals of the New York Academy of Sciences·Shuang WangLucila Ohno-Machado


Apr 5, 2019·Current Opinion in HIV and AIDS·Sanjay R MehtaSusan Little
Feb 6, 2020·JMIR Medical Informatics·Mengchun GongZhouguang Hui
Feb 14, 2019·Briefings in Bioinformatics·Abukari Mohammed Yakubu, Yi-Ping Phoebe Chen
Dec 22, 2017·NPJ Genomic Medicine·Shuang WangLucila Ohno-Machado
Aug 16, 2019·Journal of Medical Internet Research·Michael JonesNoah Zimmerman

Related Concepts

Cloud Computing
Genetic Screening Method
Computer Programs and Programming
Data Security
Sequence Determinations, DNA
Biomedical Research
Computer Software
Healthcare Services

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.