Presaturation Power Adjusted Pulsed CEST: A Method to Increase Independence of Target CEST Signals.

Contrast Media & Molecular Imaging
Kazufumi KikuchiMasaya Takahashi

Abstract

Chemical exchange saturation transfer (CEST) imaging has been demonstrated to discuss the concentration changes of amide proton, glutamate, creatine, or glucose measured at 3.5, 3.0, 2.0, and 1.0-1.2 ppm. However, these peaks in z-spectra are quite broad and overlap with each other, and thus, the independence of a CEST signal on any specific metabolite is still open to question. Here, we described whether there was interference among the CEST signals and how these CEST signals behave when the power of the presaturation pulse was changed. Based on these results, further experiments were designed to investigate a method to increase the independence of the CEST signal in both phantoms and animals. The result illustrates a clear interference among CEST signals. A presaturation power adjusted pulsed- (PPAP-) CEST method which was designed based on the exchange rates of the metabolites can be used to remove contributions from other exchanging species in the same sample. Further, the method was shown to improve the independence of the glutamate signal in vivo in the renal medulla in mice. The PPAP-CEST method has the potential to increase the independence of any target CEST signals in vivo by choosing the appropriate combination of pu...Continue Reading

References

Jan 1, 1975·Pflügers Archiv : European journal of physiology·G M EisenbachH Stolte
Apr 1, 1983·Epilepsia·B F BourgeoisJ A Ferrendelli
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter C M van ZijlSusumu Mori
Dec 4, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinyuan ZhouPeter C M van Zijl
May 4, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinyuan ZhouPeter C M Van Zijl
Aug 8, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Craig K JonesJinyuan Zhou
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peter C M van ZijlA Dean Sherry
Oct 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jimin RenA Dean Sherry
Apr 10, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mina KimPeter C M van Zijl
Jul 3, 2009·The American Journal of Clinical Nutrition·Richard A Hawkins
Apr 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tao JinSeong-Gi Kim
Jan 17, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G VarmaE Vinogradov
Jan 25, 2012·Nature Medicine·Kejia CaiRavinder Reddy
Oct 18, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kannie W Y ChanPeter C M van Zijl
Apr 16, 2013·NeuroImage·Feliks KoganRavinder Reddy
Mar 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Koji SagiyamaMasaya Takahashi
Apr 2, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stuart E Dryer
Feb 19, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hye-Young HeoJinyuan Zhou
Jul 8, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Osamu TogaoHiroshi Honda
Oct 25, 2016·Journal of Neurochemistry·Puneet BaggaRavinder Reddy

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance

Software Mentioned

Fiji
MATLAB
ImageJ
GraphPad
Prism
WASSR

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.