PMID: 16639268Apr 28, 2006Paper

Presbycusic neuritic degeneration within the osseous spiral lamina

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Margaret A ChenFred H Linthicum

Abstract

To describe a neglected anatomic variant occurring with presbycusis. Retrospective temporal bone histopathology study. Quantitative analysis of peripheral hair cells, neurites, neurons, and the stria vascularis in temporal bones from individuals who had presbycusis. Fifty-three patients aged 65 years or older and with a down-sloping audiogram and clinical diagnosis of presbycusis were reviewed. Nine cases had normal hair and ganglion cell populations but reduced peripheral processes (neuritic presbycusis). These were compared with five normal-hearing controls on measurements of anterior middle and basal turn fiber bundle diameter and the ratio of basal to middle diameters. Thresholds at 4 and 8 kHz were significantly poorer in the neuritic presbycusis group than in the control group (p<or=0.004 and 0.05, respectively), as was speech discrimination score (p<or=0.028). The ratio of basal to middle turn diameters was significantly smaller in the neuritic presbycusis group (p<or=0.003). This effect was quite marked in that there was no overlap in ratios between the groups, with the maximum neuritic presbycusis group ratio smaller than the minimum control group ratio. There was a moderate negative correlation between ratio and thres...Continue Reading

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Citations

Mar 28, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Fred H Linthicum, Jose N Fayad
Aug 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yevgeniya SergeyenkoSharon G Kujawa
Feb 26, 2014·The Journal of Physiology·Paul Albert Fuchs
Oct 16, 2015·Brain : a Journal of Neurology·Gary Rance, Arnold Starr
Jun 11, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Habib Georges Rizk, Fred H Linthicum
May 9, 2019·Journal of Neuroscience Research·Elizabeth M Keithley
Feb 24, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Prithwijit RoychowdhuryAaron K Remenschneider
Oct 27, 2018·Hearing Research·Naomi F BramhallDawn Konrad-Martin

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