Prescription medication use and antinuclear antibodies in the United States, 1999-2004

Journal of Autoimmunity
Gregg E DinseFrederick W Miller

Abstract

Clinical reports link specific medications with the development of antinuclear antibodies (ANA), but population-based evidence is limited. The present study investigated associations between prescription medication use and ANA in a representative sample of the adult noninstitutionalized US population, first focusing on medications previously related to ANA and then considering all medications reported in the National Health and Nutrition Examination Survey (NHANES). Based on NHANES data (1999-2004) for 3608 adults (ages ≥18 years), we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to assess associations between recent medication use and ANA (overall and in sex and age subgroups), adjusted for potential confounders and the survey sampling design. We found no evidence that most medications previously associated with ANA in specific individuals were risk factors for ANA in the general population, although statistical power was limited for some medications. Overall, ANA were less prevalent in adults who recently used any prescription medications compared with those who did not (OR = 0.73; CI = 0.57,0.93), and likewise several classes of medications were inversely associated with ANA, including hormones (OR = 0.73; C...Continue Reading

Citations

Oct 2, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Henry P ParkmanUNKNOWN NIDDK Gastroparesis Clinical Research Consortium

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