Prescription of and adherence to non-steroidal anti-inflammatory drugs and gastroprotective agents in at-risk gastrointestinal patients.

The American Journal of Gastroenterology
Angel LanasJavier Zapardiel

Abstract

Patients with gastrointestinal (GI) risk factors who take non-steroidal anti-inflammatory drugs (NSAIDs) should also take gastroprotective agents (GPAs). No studies have evaluated adherence and reasons for non-adherence to GPA and NSAID therapies. This was a prospective, multicenter, observational, longitudinal study. Patients attending rheumatology/orthopedic clinics who were co-prescribed NSAID plus GPA for at least 15 days and had risk factors for GI complications were followed up by telephone call. Optimal adherence was defined as taking the drug for ≥ 80% of prescribed days. Multivariate logistic regression analysis was used to determine factors associated with non-adherence. Of 1,232 patients interviewed, 192 were excluded because of inaccurate data. Of the remaining 1,040 patients, 74 % were prescribed low-dose NSAIDs and 99.8 % were prescribed a standard or high-dose GPA. In all, 70 % of NSAIDs and 63.1 % of GPA prescriptions were short term (< 30 days). The majority of patients who were prescribed either an NSAID (92.5 % ) or GPA (85.9 % ) started therapy. Optimal adherence to GPA or NSAIDs was reported by 79.7 % (95 % confidence interval (CI): 76.9-82.2 % ) and 84.1 % (95 % CI: 81.7-86.3 % ) of patients, respectively....Continue Reading

References

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Citations

Jul 9, 2014·PloS One·Antonio González-PérezLuis A García Rodríguez
Jul 15, 2015·The Physician and Sportsmedicine·Alfonso E BelloRobert J Holt
Mar 1, 2013·Current Medical Research and Opinion·Karin S CoyneAshish V Joshi
May 12, 2012·Revista española de geriatría y gerontología·Carlos Sostres, Angel Lanas
May 8, 2018·Journal of Digestive Diseases·Hooi Leng LeeSanjiv Mahadeva
Aug 15, 2013·Pain Practice : the Official Journal of World Institute of Pain·Robert Andrew MoorePaul Emery
Sep 6, 2013·The Tohoku Journal of Experimental Medicine·Toshimitsu IwabuchiTooru Shimosegawa
Dec 31, 2019·International Journal of Rheumatic Diseases·Sang-Hoon LeeTae-Hwan Kim
Nov 25, 2017·Pharmacoepidemiology and Drug Safety·Michèle BallyJames M Brophy
Aug 17, 2021·Pharmacoepidemiology and Drug Safety·Mirjam HempeniusHelga Gardarsdottir

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