Prescription of Potentially Harmful Drugs in Young Adults With Heart Failure and Reduced Ejection Fraction

The American Journal of Cardiology
Paulino A AlvarezCecilia Ganduglia-Cazaban

Abstract

According to national guidelines and statements drugs that can cause or exacerbate heart failure (HF) are considered potentially harmful and should be avoided if possible in patients with a diagnosis of heart failure with reduced ejection fraction (HFREF). To evaluate the prevalence of potentially harmful drug (PHD) prescription among patients with a diagnosis of systolic heart failure we conducted a retrospective cohort study using Truven Health MarketScan Commercial database from 2011 to 2014. Prescription of PHD as defined by American Heart Association Statement was examined among patients with a HFREF diagnosis in: (1) Two outpatient encounters, (2) One inpatient encounter as primary diagnosis and/or (3) one inpatient encounter any position and one outpatient encounter. Among 40,966 patients, 24.2% were prescribed with at least 1 drug with the potential to cause or exacerbate heart failure. Of the 9,954 patients prescribed with PHD, nonsteroidal anti-inflammatory agents were the most frequent category prescribed (67.4%), followed by antihypertensive (24%), diabetes mellitus (23.3%), neurological and psychiatric (21%) and antiarrhythmic medications (12.6%). After multivariable analysis female patients, the presence of a como...Continue Reading

Citations

Feb 23, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Armando Silva Almodóvar, Milap C Nahata
May 19, 2020·ESC Heart Failure·Paulino A AlvarezMary S Vaughan Sarrazin
Mar 5, 2020·JACC. Heart Failure·Paulino Alvarez, Alexandros Briasoulis
Jul 3, 2021·Heart Failure Reviews·Janine BeezerPaul Forsyth

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