Prescription opioid use before and after kidney transplant: Implications for posttransplant outcomes

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Krista L LentineMark A Schnitzler

Abstract

Evolving literature suggests that the epidemic of prescription opioid use affects the transplant population. We examined a novel database wherein national U.S. transplant registry records were linked to a large pharmaceutical claims warehouse (2007-2015) to characterize prescription opioid use before and after kidney transplant, and associations (adjusted hazard ratio, 95%LCL aHR95%UCL ) with death and graft loss. Among 75 430 eligible patients, 43.1% filled opioids in the year before transplant. Use was more common among recipients who were women, white, unemployed, publicly insured, and with longer pretransplant dialysis. Of those with the highest level of pretransplant opioid use, 60% continued high-level use posttransplant. Pretransplant opioid use had graded associations with one-year posttransplant outcomes; the highest-level use predicted 46% increased risk of death (aHR 1.28 1.461.66 ) and 28% increased risk of all-cause graft failure (aHR 1.17 1.281.41 ). Effects of high-level opioid use in the first year after transplant were stronger, predicting twice the risk of death (aHR 1.93 2.242.60 ) and 68% higher all-cause graft failure risk (aHR 1.50 1.681.89 ) over the subsequent year; increased risk persisted over five yea...Continue Reading

References

May 1, 1997·Journal of Clinical Epidemiology·H S LauA Porsius
Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Manjula KurellaGlenn M Chertow
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sara N Davison
Oct 27, 2004·Journal of Pain and Symptom Management·Mervyn Dean
Jun 25, 2005·Journal of the American Society of Nephrology : JASN·Steven D WeisbordGalen E Switzer
Feb 26, 2009·Postgraduate Medical Journal·E M SalisburyE A Brown
Jan 1, 2010·Current Drug Targets·Pasquale NiscolaRoberto Palumbo
Dec 24, 2010·Seminars in Dialysis·Phuong-Thu PhamGabriel Danovitch
Apr 7, 2011·JAMA : the Journal of the American Medical Association·Amy S B BohnertFrederic C Blow
Aug 2, 2012·JAMA : the Journal of the American Medical Association·Lewis S Nelson, Jeanmarie Perrone
Feb 20, 2015·Clinical Orthopaedics and Related Research·Mariano E MenendezBrian T Bateman
Apr 4, 2015·American Journal of Nephrology·Krista L LentineMark A Schnitzler
Sep 3, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K L LentineD L Segev
Dec 28, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Henry B RandallKrista L Lentine
Mar 28, 2017·Substance Use & Misuse·Cynthia I CampbellConstance Weisner
Jul 26, 2017·Transplantation·Krista L LentineAmit X Garg
Aug 29, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L C Pullen
Sep 25, 2017·Journal of the American Society of Nephrology : JASN·Paul L KimmelPaul W Eggers
Sep 28, 2017·Journal of Opioid Management·Bernd A WollschlaegerVijay R Nadipelli

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Citations

Oct 3, 2019·Transplantation Direct·Krista L LentineMark A Schnitzler
Jun 12, 2020·Clinical Transplantation·Vinayak S RohanJames N Fleming
Aug 10, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Krista L LentineMark A Schnitzler
Feb 6, 2020·Transplantation·David C CronChristopher J Sonnenday
Feb 2, 2021·Clinical Transplantation·Michele A MuirPablo Serrano Rodriguez
Apr 14, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Krista L LentineMark A Schnitzler
Apr 11, 2021·Clinical Transplantation·Shukri H A DualehSarah Tischer
Apr 27, 2021·Seminars in Nephrology·Marie-Camille LafargueLeonardo V Riella
May 4, 2021·The Journal of Surgical Research·Marisa Eve SchwabRyutaro Hirose
Jul 24, 2021·Clinical Transplantation·Jon SussmanAmit K Mathur

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