Prescription rate of medications potentially contributing to lower urinary tract symptoms and detection of adverse reactions by prescription sequence symmetry analysis

Journal of Pharmaceutical Health Care and Sciences
Masako HashimotoKunizo Arai

Abstract

The lower urinary tract symptoms (LUTS) increases with age and can have a significant effect on the quality of life of the patients. Elderly patients, who are often characterized by a decline in physiological functional and polypharmacy, are susceptible to adverse drug reactions to pharmacotherapy. LUTS can also be a side effect of medication. The purpose of this study was to investigate the possible association between the initiation of LUTS-causing drug therapy and the onset of LUTS. Drug dispensing data at the individual level were retrieved from the CISA (Platform for Clinical Information Statistical Analysis: http://www.cisa.jp) database. A retrospective study was conducted by reviewing patients with LUTS who were dispensed drugs that increased the risk of LUTS between April 2011 and March 2012. Prescription sequence symmetry analysis (PSSA) was employed to investigate the associations between the dispensing of medicines of LUTS and that of LUTS-causing drugs. LUTS-causing drugs were frequently dispensed to patients with LUTS. The use of medications potentially contributing to LUTS was associated with polypharmacy [number of prescription drugs:12.13 ± 6.78 (user) vs. 5.67 ± 5.24 (nonuser)] but not patient age [ age: (71.38...Continue Reading

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Citations

Nov 11, 2017·International Psychogeriatrics·Lisa M Kalisch EllettElizabeth E Roughead
Feb 10, 2019·Clinical and Experimental Pharmacology & Physiology·Keisuke ObaraYoshio Tanaka
Jan 15, 2016·Current Opinion in Urology·Amanda ChungVincent Tse
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Jan 10, 2021·Brain Sciences·Ana Gómez-LópezAraceli Alonso-Canovas
Aug 12, 2021·Research in Social & Administrative Pharmacy : RSAP·Earl J MorrisScott M Vouri

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Methods Mentioned

BETA
urine stream
hormone replacement therapies
CISA
lavage

Software Mentioned

PSSA

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