Presence and biological activity of C-type natriuretic peptide-dependent guanylate cyclase-coupled receptor in the penile corpus cavernosum

The Journal of Urology
Sung Zoo KimK W Cho

Abstract

To investigate the presence of C-type natriuretic peptide 1-22 (CNP)-dependent guanylyl cyclase (GC)-coupled receptor and its biological function in the penile erectile smooth muscle. Experiments have been done in rabbit and rat to detect cyclic GMP (cGMP) generation by the activation of particulate GC by natriuretic peptides (NPs) in cavernosal membrane, to localize precise receptor using a quantitative in vitro autoradiography of the snap frozen sections, to define natriuretic peptide receptor (NPR) mRNA using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique and to monitor changes of erectile smooth muscle tone by NPs in the penile tissue strips. Productions of cGMP by particulate GC in the corpus cavernosum membranes of rabbit and rat were stimulated by CNP, atrial natriuretic peptide 1-28 (ANP) and brain natriuretic peptide 1-26 (BNP) with a rank order of potency of CNP > BNP > ANP. HS-142-1, a selective antagonist for the GC-coupled NPR, inhibited the CNP-stimulated cGMP production in corpus cavernosal membrane of rabbit and rat. Specific 125I-(Tyr[0])-CNP bindings were localized in the corpus cavernosal smooth muscle of rabbit with Kd of 19.92+/-3.38 nM. and Bmax of 734.64+/-139.63 amol./mm2. B-subtype...Continue Reading

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Citations

May 25, 2011·Journal of Natural Medicines·Jun Kyoung LeeHo-Sub Lee
Mar 9, 2004·Regulatory Peptides·Feng Lian PiaoSuhn Hee Kim
Oct 16, 2001·Regulatory Peptides·S H KimK W Cho
Jul 11, 2001·Peptides·S H KimK W Cho
Jan 12, 2002·Peptides·J H KimS H Kim
Jan 12, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Xiang LiHo Sub Lee
Dec 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Yong Pyo LeeHo Sub Lee
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