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Presence and expression of JCV early gene large T Antigen in the brains of immunocompromised and immunocompetent individuals

Journal of Medical Virology

Dec 2, 2008

Serena DelbuePasquale Ferrante

Abstract

JC virus (JCV) is a polyomavirus that asymptomatically infects up to 80% of the worldwide human population and establishes latency in the kidney. In the case of host immunodeficiency, it can cause progressive multifocal leukoencephalopathy (PML), which is a fatal demyelinating disease o...read more

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Pathogenic Aspects
Pathogenesis
Immunohistochemistry
Immunologic Deficiency Syndromes
Leukoencephalopathy, Progressive Multifocal
Autopsy
Viral Tumor Antigens
Viral Proteins
Graft-vs-Host Disease
Paper Details
References
  • References19
  • Citations26
12
  • References19
  • Citations26
123

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Presence and expression of JCV early gene large T Antigen in the brains of immunocompromised and immunocompetent individuals

Journal of Medical Virology

Dec 2, 2008

Serena DelbuePasquale Ferrante

PMID: 19040292

DOI: 10.1002/jmv.21313

Abstract

JC virus (JCV) is a polyomavirus that asymptomatically infects up to 80% of the worldwide human population and establishes latency in the kidney. In the case of host immunodeficiency, it can cause progressive multifocal leukoencephalopathy (PML), which is a fatal demyelinating disease o...read more

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Pathogenic Aspects
Pathogenesis
Immunohistochemistry
Immunologic Deficiency Syndromes
Leukoencephalopathy, Progressive Multifocal
Autopsy
Viral Tumor Antigens
Viral Proteins
Graft-vs-Host Disease

Similar Papers Found In These Feeds

Progressive Multifocal Leukoencephalopathy (PML)

Progressive Multifocal Leukoencephalopathy (PML) occurs due to JC virus infection. While most adults are infected, PML emerges in individuals with weakened immune systems. Here is the latest on PML.

Seroconversion

Seroconversion is defined as the time when a specific antibody becomes detectable in the blood. Discover the latest research on seroconversion here.

Related Papers

Annals of Neurology

Detection of JC virus DNA fragments but not proteins in normal brain tissue

Annals of NeurologyAugust 9, 2008
Georgina Perez-LizK Khalili
Pathology

Immunosuppression increases latent infection of brain by JC polyomavirus

PathologyMay 3, 2011
Julianne BaylissCatriona Ann McLean
Paper Details
References
  • References19
  • Citations26
12
  • References19
  • Citations26
123
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