Presence of 11-ketotestosterone in pre-differentiated male gonads of Odontesthes bonariensis.

Fish Physiology and Biochemistry
Martín BlascoDenise Vizziano-Cantonnet

Abstract

The involvement of androgens during sex differentiation period was investigated in the pejerrey Odontesthes bonariensis, by classic biochemical studies and gonadal histology. We studied in particular whether the enzyme activities involved in 11-oxygenated androgen production were active in a gonadal/peritoneum complex (GPC) of very small larvae exposed to masculinizing temperatures previous to morphological sex differentiation (5 weeks post-hatching). The GPC was incubated with 17-hydroxyprogesterone ((3)H-17P), and the presence of 11-KT as major metabolite in early gonads undergoing masculine pathway after temperature treatment exposure is reported. 11-KT was identified by thin-layer chromatography and high-pressure liquid chromatography. The present results show that 11-KT is produced at very early stages of testis development in pejerrey, being this androgen one of the main mediators of the masculinization induced by temperature treatment at the gonad level.

References

Jun 23, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Denise VizzianoYann Guiguen
Mar 18, 2009·General and Comparative Endocrinology·Yann GuiguenChing-Fong Chang
Jan 19, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Martín BlascoDenise Vizziano-Cantonnet
Jul 14, 2010·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Masahisa Nakamura

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Citations

Oct 16, 2015·Molecular Reproduction and Development·Denise Vizziano-CantonnetIrani Quagio-Grassiotto
May 24, 2012·Molecular Reproduction and Development·Julio BerbejilloDenise Vizziano-Cantonnet

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