Presence of Air Trapping and Mosaic Attenuation on Chest Computed Tomography Predicts Survival in Chronic Hypersensitivity Pneumonitis

Annals of the American Thoracic Society
Jonathan H ChungEvans R Fernández Pérez

Abstract

Significant heterogeneity of computed tomography (CT) presentation exists within chronic hypersensitivity pneumonitis (HP). There are limited data aimed at delineating the prognostic value of specific CT features, distribution, and patterns in chronic HP. To examine whether the presence of CT mosaic attenuation (MA) and air trapping (AT), and the distribution or patterns of fibrosis impact survival in subjects with chronic HP. We retrospectively identified 110 consecutively enrolled, well-characterized, biopsy-proven adult subjects with chronic HP between 1982 and 2015 from the National Jewish Health interstitial lung disease research database. The first available CT scan of diagnostic quality from each subject was formally evaluated for specific CT findings associated with chronic HP and for overall CT pattern. A Cox proportional hazards model was used to identify independent predictors in time-to-death analysis, and bootstrap analysis was performed for internal model validation. Fibrotic HP (65%; 72/110) was most often peripheral in the axial plane and lower lung preponderant. The distribution of lung disease in those without fibrosis was most often axially and zonally diffuse. There was no association between survival and CT...Continue Reading

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Citations

Dec 14, 2017·Annals of the American Thoracic Society·Evans R Fernández PérezAshley L Cole
Oct 20, 2017·Expert Review of Respiratory Medicine·Olívia Meira DiasAndré Luis Pereira de Albuquerque
Dec 6, 2018·Expert Review of Respiratory Medicine·Florence JenyDominique Valeyre
Jan 17, 2019·Current Opinion in Allergy and Clinical Immunology·Ferran MorellMaría-Jesús Cruz
Sep 15, 2018·American Journal of Respiratory and Critical Care Medicine·Ayodeji AdegunsoyeJonathan H Chung
May 2, 2019·Annals of the American Thoracic Society·Evans R Fernández Pérez
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Sep 30, 2017·Annals of the American Thoracic Society·Joshua J Mooney
Mar 19, 2020·Tuberculosis and Respiratory Diseases·Paolo Maria Leone, Luca Richeldi
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Methods Mentioned

BETA
biopsy

Software Mentioned

JMP

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