Presence of aldose reductase inhibitors in tea leaves

Japanese Journal of Pharmacology
I SakaiT Suzuki

Abstract

Water extract from commercial English tea has a potent inhibitory activity against human placenta aldose reductase (NADPH oxidoreductase, E.C.1.1.1.21.). Inhibitory activity was separated into five major fractions by one-step chromatography with a C-18 reverse phase column. The most active fraction was further subjected to reverse phase column chromatography. As a result, a well-known flavone-glycoside, isoquercitrin, was isolated as the most potent chemical. The inhibitory character of isoquercitrin for aldose reductase was a mix of uncompetitive and noncompetitive inhibitions, and its IC50 was 1 x 10(-6) M. In rat sciatic nerve tissue preparations, sorbitol accumulation in the presence of high concentrations of glucose (30 mM) was inhibited by 38% at 5 x 10(-4) M of isoquercitrin. The flavone-glycoside isoquercitrin is the active inhibitor of aldose reductase inhibitor present in English tea. Given the ability of aldose reductase inhibitors to prevent diabetic complications, an epidemiological study of the effect of tea consumption on the pathogenesis and progression of diabetic complications would be interesting.

References

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Citations

Feb 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M HasumuraM Hirose
Aug 6, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T TamuraJ Kuroda
May 16, 2013·Phytotherapy Research : PTR·Ciddi VeereshamKaleab Asres
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Mahmoud BahmaniKourosh Saki
Apr 28, 2005·Journal of Agricultural and Food Chemistry·Joe A Vinson, Juan Zhang

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