Presence of anti-citrullinated protein antibodies and costs and disease activity in early rheumatoid arthritis - a 3-year follow-up.

Scandinavian Journal of Rheumatology
M HusbergE Hallert

Abstract

Objective: To analyse healthcare utilization, loss of productivity, and disease activity in relation to presence of anti-citrullinated protein antibodies (ACPAs). Method: In total, 447 ACPA-positive and 224 ACPA-negative patients from two early rheumatoid arthritis cohorts, recruited 1996-1998 (cohort 1) and 2006-2009 (cohort 2), were followed during 3 years. Data on disease activity were collected, and patients reported healthcare utilization and days lost from work. Disease activity, healthcare costs, and loss of productivity were compared between ACPA groups. Linear regression was performed, controlling for confounders. Results: Healthcare costs did not differ significantly by ACPA status (EUR 3214 for vs EUR 2174 for ACPA-positive vs ACPA-negative patients in cohort 1, ns; EUR 4150 vs EUR 3820 in cohort 2, ns). Corresponding values for loss of productivity were EUR 9148 vs EUR 7916 (ns) and EUR 5857 vs EUR 5995 (ns). Total prescription of traditional disease-modifying anti-rheumatic drugs was higher in cohort 2 than in cohort 1. Methotrexate prescription was higher in ACPA-positive patients, but biologics did not differ significantly between ACPA groups. Disease activity was significantly more improved in cohort 2, but ther...Continue Reading

References

Jan 22, 2000·Arthritis and Rheumatism·G A SchellekensW J van Venrooij
Apr 28, 2000·BMJ : British Medical Journal·S G Thompson, J A Barber
Apr 16, 2003·Annals of the Rheumatic Diseases·J VencovskýS Růzicková
Mar 3, 2012·PharmacoEconomics·Howard G BirnbaumMary Cifaldi
May 27, 2014·PharmacoEconomics·Till UhligTore K Kvien
Jan 2, 2018·Journal of Managed Care & Specialty Pharmacy·Jason ShafrinKaleb Michaud

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