Presence of antibodies reacting with porcine circovirus in sera of humans, mice, and cattle

Archives of Virology
I TischerE Gerike

Abstract

Antibodies reacting with porcine circovirus (PCV) were found in sera of humans, mice, and cattle by means of an indirect immunofluorescence assay (IFA) and an ELISA. In man, the highest seroprevalence (23.9% in IFA and 30.2% in ELISA) was found among hospitalized patients with fever of partially unclear etiology. Non-hospitalized "healthy" persons of the former German Democratic Republic showed a significantly higher number of positive sera (IFA = 20%) than blood donors from Berlin-West (IFA = 8.6%). Murine sera reacted positive with PCV in IFA between 12 to 69% in different breeding groups and about 35% of cattle sera were found reactive with PCV in IFA. Double-staining IFAs, immuno-electron microscopy and immunoblotting showed that non-porcine antibodies reacted with PCV structural antigen. Mathematical analysis revealed that in ELISA, non-porcine antibodies reacted specifically with PCV. Loss of binding specificity of non-porcine antibodies in ELISA after storage of sera and lower maximal optical densities obtained at equal titers in ELISA with non-porcine than with porcine sera suggest that antibodies in man, mice and cattle are caused by related species specific viruses sharing antigenic epitopes with PCV.

Citations

Oct 15, 2013·Biologicals : Journal of the International Association of Biological Standardization·Peter D BurbeloYanjin Zhang
Nov 23, 2010·Animal Health Research Reviews·A R Patterson, T Opriessnig
Apr 6, 2006·Animal Health Research Reviews·Joaquim SegalésMariano Domingo
Oct 1, 2000·Avian Pathology : Journal of the W.V.P.A·D Todd
Jan 10, 2012·Transboundary and Emerging Diseases·X J Meng
Sep 29, 2009·Journal of Veterinary Internal Medicine·J GillespieV Buechner-Maxwell
Nov 6, 2004·Journal of Clinical Microbiology·O GarkavenkoR B Elliott
Jan 11, 2000·Journal of Virology·H OkamotoM Mayumi
Dec 8, 2000·Journal of the American Veterinary Medical Association·J A EllisF McNeilly
Sep 25, 2014·Virus Genes·Shao-Lun ZhaiWen-Kang Wei
Oct 18, 2011·Biologicals : Journal of the International Association of Biological Standardization·Carol Marcus-SekuraRebecca L Sheets
Mar 10, 2010·The Veterinary Journal·Llorenç Grau-RomaJoaquim Segalés
Oct 6, 2005·Xenotransplantation·Gabriel Arteaga-TroncosoSaúl Flores-Medina
Feb 6, 2009·The Journal of Gene Medicine·Kandan AravindaramNing-Sun Yang
Apr 6, 2005·Transplantation Proceedings·O GarkavenkoM C Croxson
Aug 3, 2014·Veterinary Microbiology·Mohammad Y HalamiThomas W Vahlenkamp
Dec 3, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Shao-Lun ZhaiWen-Kang Wei
Nov 26, 2010·Vaccine·Sally A BaylisAnnette Mankertz
Apr 21, 2017·Viruses·Joachim Denner, Annette Mankertz
Oct 12, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Qianyue JinGaiping Zhang
Dec 7, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·T SirinarumitrP S Paul
Nov 9, 2002·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Roman M PogranichniyMichael Daniels
Nov 14, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tanja OpriessnigPatrick G Halbur
Dec 26, 2003·Journal of Medical Virology·Olga GarkavenkoMargaret C Croxson
Oct 17, 2019·Frontiers in Veterinary Science·Shao-Lun ZhaiYun Xi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.