PMID: 2492776Jan 1, 1989Paper

Presence of antibodies to the major surface glycoprotein of Trypanosoma cruzi amastigotes in sera from Chagasic patients

The American Journal of Tropical Medicine and Hygiene
N W AndrewsV Nussenzweig

Abstract

The surface of amastigote forms of Trypanosoma cruzi is covered by a stage-specific glycoprotein, Ssp-4. We show that Y strain-derived Ssp-4 is recognized by antibodies in sera from Chagasic patients. All 51 sera reacted with the surface of amastigotes by indirect immunofluorescence assays and immunoprecipitated Ssp-4. The human antibodies inhibited the binding of monoclonal antibodies to Ssp-4 in immunoradiometric assays, suggesting that the corresponding region of the molecule may be conserved among distinct strains of the parasite.

Citations

Feb 5, 2005·Anais Da Academia Brasileira De Ciências·Renato A MortaraSolange da Silva
Oct 29, 2005·Microbes and Infection·Vanina A CampoAlberto Carlos C Frasch
Jun 2, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marybell Olivas-RubioJosé Luis Rosales-Encina

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