Abstract
Recent studies in several laboratories are focused on delineating sperm antigens that are relevant to fertility and examining involvement of antibodies to these antigens in human immunoinfertility. Our laboratory has characterized two such antigens, namely fertilization antigen (FA-1) and YLP12 dodecamer sequence that are involved in sperm-oocyte binding. The present study was conducted to examine the occurrence of isoantibodies to various peptide epitopes of human and murine FA-1 antigen and YLP12 peptide in sera of immunoinfertile and fertile women. Sera from 67 immunoinfertile and 19 fertile women were collected. Various peptides based up on human and murine FA-1 antigen and YLP(12) were synthesized, and examined for immunoreactivity with these sera by using ELISA. Four immunodominant sequences, two each from human (hFA-1 82-97aa and hFA-1 200-219aa) and mouse (mFA-1 2-19aa and mFA-1 117-136aa) FA-1 antigen, were selected for the present study. Another human FA-1 sequence, hFA-1 220-240aa, that was not in the immunodominant region was used as a control. For human FA-1 peptides, 41.8% of the immunoinfertile sera reacted positively (>or=2 SD units) with hFA-1 82-97aa, 24.6% (16/65) with hFA-1 200-219aa, and 3% (2/66) with hFA-...Continue Reading
References
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Jul 24, 2002·Biology of Reproduction·Rajesh K Naz, Subhash C Chauhan
Aug 31, 2002·Molecular Reproduction and Development·Rajesh K Naz, Xiaolong Zhu
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Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·Rajesh K Naz
Sep 26, 2006·Molecular Reproduction and Development·Satish Bhande, Rajesh K Naz
Aug 7, 2007·Molecular Reproduction and Development·Rajesh K Naz
Citations
Mar 29, 2008·Human Reproduction·A S Samuel, R K Naz
Feb 6, 2016·Cell and Tissue Research·Jun FuLinfang Wang
Feb 23, 2013·Actas urologicas españolas·B Restrepo, W Cardona-Maya
Feb 19, 2013·Journal of Reproductive Immunology·Rajesh K Naz, Thomas S Butler
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Apr 12, 2014·Protein Science : a Publication of the Protein Society·Rajesh K Naz
May 28, 2014·American Journal of Reproductive Immunology : AJRI·Mónica H Vazquez-LevinCarolina Veaute