Presence of antisperm antibodies reactive with peptide epitopes of FA-1 and YLP12 in sera of immunoinfertile women

American Journal of Reproductive Immunology : AJRI
Jessica WilliamsR K Naz

Abstract

Recent studies in several laboratories are focused on delineating sperm antigens that are relevant to fertility and examining involvement of antibodies to these antigens in human immunoinfertility. Our laboratory has characterized two such antigens, namely fertilization antigen (FA-1) and YLP12 dodecamer sequence that are involved in sperm-oocyte binding. The present study was conducted to examine the occurrence of isoantibodies to various peptide epitopes of human and murine FA-1 antigen and YLP12 peptide in sera of immunoinfertile and fertile women. Sera from 67 immunoinfertile and 19 fertile women were collected. Various peptides based up on human and murine FA-1 antigen and YLP(12) were synthesized, and examined for immunoreactivity with these sera by using ELISA. Four immunodominant sequences, two each from human (hFA-1 82-97aa and hFA-1 200-219aa) and mouse (mFA-1 2-19aa and mFA-1 117-136aa) FA-1 antigen, were selected for the present study. Another human FA-1 sequence, hFA-1 220-240aa, that was not in the immunodominant region was used as a control. For human FA-1 peptides, 41.8% of the immunoinfertile sera reacted positively (>or=2 SD units) with hFA-1 82-97aa, 24.6% (16/65) with hFA-1 200-219aa, and 3% (2/66) with hFA-...Continue Reading

References

Nov 1, 1987·The Journal of Clinical Investigation·R K Naz
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R K NazB B Rosenblum
Oct 1, 1995·Urology·D A Ohl, R K Naz
May 1, 1994·Fertility and Sterility·P B Marshburn, W H Kutteh
Nov 1, 1993·The Journal of Clinical Investigation·R K NazA C Menge
Apr 1, 1993·Human Reproduction·J A CollinsE V YoungLai
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·X Zhu, R K Naz
Jul 13, 1999·Human Reproduction·F M HelmerhorstJ J Erwich
Dec 3, 1999·Immunological Reviews·R K Naz
Sep 30, 1999·Nihon rinsho. Japanese journal of clinical medicine·K Koyama
Jul 24, 2002·Biology of Reproduction·Rajesh K Naz, Subhash C Chauhan
Aug 31, 2002·Molecular Reproduction and Development·Rajesh K Naz, Xiaolong Zhu
Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·Rajesh K Naz
Sep 26, 2006·Molecular Reproduction and Development·Satish Bhande, Rajesh K Naz
Aug 7, 2007·Molecular Reproduction and Development·Rajesh K Naz

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Citations

Feb 6, 2016·Cell and Tissue Research·Jun FuLinfang Wang
Feb 23, 2013·Actas urologicas españolas·B Restrepo, W Cardona-Maya
Feb 19, 2013·Journal of Reproductive Immunology·Rajesh K Naz, Thomas S Butler
Jan 3, 2013·American Journal of Reproductive Immunology : AJRI·Sydney Clark, Rajesh K Naz
Apr 12, 2014·Protein Science : a Publication of the Protein Society·Rajesh K Naz
May 28, 2014·American Journal of Reproductive Immunology : AJRI·Mónica H Vazquez-LevinCarolina Veaute

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