Presence of autoimmune disease affects not only risk but also survival in patients with B-cell non-Hodgkin lymphoma

Hematological Oncology
Geffen KleinsternOra Paltiel

Abstract

Although autoimmune diseases (AIDs) are known to predispose to non-Hodgkin lymphoma (NHL), their association with NHL prognosis has rarely been investigated. We examined associations between autoimmunity and B-cell NHL onset by comparing AID history (determined by self-report and medication review and supplemented by chart review where possible) among 435 adult B-NHL patients in Hadassah-Hebrew University Medical Center, diagnosed 2009-2014, and 414 age-and-sex frequency-matched controls. We examined AIDs as a whole, B- and T-cell-mediated AIDs, and autoimmune thyroid diseases. Among cases, we used Kaplan-Meier and Cox regression models to assess the association of AID with overall survival and relapse-free survival, adjusting for prognostically important patient and disease characteristics such as Ki67% staining, International Prognostic Index, rituximab treatment, and histological subgroup. Autoimmune diseases were associated with B-NHL (odds ratio [OR] = 1.95; 95% confidence interval (CI), 1.31-2.92), especially AIDs mediated by B-cell activation (OR = 5.20; CI, 1.90-14.3), which were particularly associated with marginal zone lymphoma (OR = 19.3; CI, 4.59-80.9). We found that time to relapse for all B-NHL patients with AIDs...Continue Reading

References

Jan 21, 1985·The American Journal of Medicine·T HakulinenP Knekt
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Jun 1, 1996·Arthritis and Rheumatism·M Abu-ShakraM B Urowitz
Jun 1, 1997·Leukemia & Lymphoma·A H SarrisF Cabanillas
Nov 17, 2005·Archives of Internal Medicine·Elias ZintzarasHaralampos M Moutsopoulos
Apr 15, 2009·International Journal of Cancer. Journal International Du Cancer·Lesley A AndersonEric A Engels
Oct 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ola LandgrenMagnus Björkholm
Nov 20, 2012·International Journal of Cancer. Journal International Du Cancer·Julia F SimardKarin E Smedby
Aug 2, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M FallahK Hemminki
Sep 1, 2014·Journal of the National Cancer Institute. Monographs·Lindsay M MortonJoshua N Sampson
Feb 26, 2015·American Journal of Epidemiology·Sophia S WangKarin E Smedby
Jun 30, 2016·PloS One·Kari HemminkiAsta Försti

❮ Previous
Next ❯

Citations

Jan 27, 2019·Cornea·Esen K AkpekIan J Saldanha
Aug 3, 2018·Blood Cancer Journal·Geffen KleinsternJames R Cerhan
Sep 26, 2019·The Journal of International Medical Research·Hui LiuRong Fu
Feb 5, 2021·Journal of Clinical Medicine·Peter C TaylorJanet Pope
Oct 30, 2020·Journal of Clinical Medicine·Pierluigi MasciopintoFrancesco Albano
Aug 19, 2021·American Journal of Clinical Pathology·Xuan J WangNidhi Aggarwal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Kevin TaySoon-Thye Lim
[Rinshō ketsueki] The Japanese journal of clinical hematology
Tomohiro Kinoshita
© 2022 Meta ULC. All rights reserved