Abstract
Although autoimmune diseases (AIDs) are known to predispose to non-Hodgkin lymphoma (NHL), their association with NHL prognosis has rarely been investigated. We examined associations between autoimmunity and B-cell NHL onset by comparing AID history (determined by self-report and medication review and supplemented by chart review where possible) among 435 adult B-NHL patients in Hadassah-Hebrew University Medical Center, diagnosed 2009-2014, and 414 age-and-sex frequency-matched controls. We examined AIDs as a whole, B- and T-cell-mediated AIDs, and autoimmune thyroid diseases. Among cases, we used Kaplan-Meier and Cox regression models to assess the association of AID with overall survival and relapse-free survival, adjusting for prognostically important patient and disease characteristics such as Ki67% staining, International Prognostic Index, rituximab treatment, and histological subgroup. Autoimmune diseases were associated with B-NHL (odds ratio [OR] = 1.95; 95% confidence interval (CI), 1.31-2.92), especially AIDs mediated by B-cell activation (OR = 5.20; CI, 1.90-14.3), which were particularly associated with marginal zone lymphoma (OR = 19.3; CI, 4.59-80.9). We found that time to relapse for all B-NHL patients with AIDs...Continue Reading
References
Jan 21, 1985·The American Journal of Medicine·T HakulinenP Knekt
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Jun 1, 1996·Arthritis and Rheumatism·M Abu-ShakraM B Urowitz
Mar 1, 1997·Cancer Causes & Control : CCC·M KauppiH Isomäki
Jun 1, 1997·Leukemia & Lymphoma·A H SarrisF Cabanillas
Nov 17, 2005·Archives of Internal Medicine·Elias ZintzarasHaralampos M Moutsopoulos
Jun 8, 2007·Leukemia·S WöhrerM Raderer
Apr 15, 2009·International Journal of Cancer. Journal International Du Cancer·Lesley A AndersonEric A Engels
Oct 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ola LandgrenMagnus Björkholm
May 17, 2011·Arthritis Research & Therapy·Hans-Peter TonyUNKNOWN GRAID investigators
Jul 15, 2011·Medical Oncology·Nada SuvajdzicBiljana Mihaljevic
Nov 20, 2012·International Journal of Cancer. Journal International Du Cancer·Julia F SimardKarin E Smedby
Aug 2, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M FallahK Hemminki
Sep 1, 2014·Journal of the National Cancer Institute. Monographs·James R CerhanChristine F Skibola
Sep 1, 2014·Journal of the National Cancer Institute. Monographs·Paige M BracciSilvia de Sanjosé
Sep 1, 2014·Journal of the National Cancer Institute. Monographs·Lindsay M MortonJoshua N Sampson
Feb 26, 2015·American Journal of Epidemiology·Sophia S WangKarin E Smedby
Jun 30, 2016·PloS One·Kari HemminkiAsta Försti
Feb 15, 2017·PloS One·Geffen KleinsternOra Paltiel
Citations
Jan 27, 2019·Cornea·Esen K AkpekIan J Saldanha
Aug 3, 2018·Blood Cancer Journal·Geffen KleinsternJames R Cerhan
Sep 26, 2019·The Journal of International Medical Research·Hui LiuRong Fu
Oct 23, 2019·Molecular Medicine Reports·Jing HanWenlin Wu
May 28, 2019·Acta Oncologica·Charlott MörthGunilla Enblad
Feb 5, 2021·Journal of Clinical Medicine·Peter C TaylorJanet Pope
Oct 30, 2020·Journal of Clinical Medicine·Pierluigi MasciopintoFrancesco Albano
Aug 19, 2021·American Journal of Clinical Pathology·Xuan J WangNidhi Aggarwal