PMID: 8608350Dec 1, 1995Paper

Presence of bacterial flora-derived antigen in synovial tissue macrophages and dendritic cells

British Journal of Rheumatology
M J MeliefM P Hazenberg

Abstract

In previous studies using and animal model human bacterial flora-derived peptidoglycan Polysaccharides were shown to be arthropathic after a single subcutaneous injection. A prerequisite for proof of the hypothesis that bacterial products from the normal resident flora are involved in the immune reaction of human chronic polyarthritis of unknown aetiology is the presence of these antigens in synovial tissue. 2E9, a monoclonal antibody we developed against intestinal peptidoglycan polysaccharides was used in a histochemical study in rats and stained macrophages in the spleen red pulp. In this study human synovial tissues from 10 rheumatoid arthritis (RA) and 20 non-RA patients were stained with 2E9. We found that eight out of 10 RA patients had 2E9-positive macrophages and dendritic cells in their synovia. A significant difference was observed with the control group in which seven out of 20 were positive. No positive cells or staining of the matrix was found in the cartilage of six RA patients. These results show that exogenous bacterial antigens are present in synovial tissue macrophages and dendritic cells. It was concluded that the unknown antigen in the immune reaction in RA is not necessarily endogenous.

Citations

Nov 3, 2010·Expert Opinion on Biological Therapy·Felix I L Clanchy, Sandra M Sacre
Apr 22, 2014·FEBS Letters·Kerstin Berer, Gurumoorthy Krishnamoorthy
Oct 30, 2012·Diagnostic Microbiology and Infectious Disease·R S van OnkelenW R Schouten
Feb 13, 2001·Clinical and Experimental Immunology·I A SchrijverJ D Laman
Aug 18, 1999·Immunological Reviews·B LudewigH Hengartner
Mar 23, 2006·Shock·Anders E MyhreJacob E Wang
May 1, 2002·Current Opinion in Rheumatology·J Alastair GracieIain B McInnes
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lizette VisserJon D Laman
Jun 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Brandon L JutrasChristine Jacobs-Wagner
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthias PiererDiego Kyburz
Feb 1, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I A SchrijverJ D Laman
May 14, 2021·Pain Reports·Conceição Elidianne Aníbal SilvaThiago Mattar Cunha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.