Presence of bile acids in human follicular fluid and their relation with embryo development in modified natural cycle IVF

Human Reproduction
R A NagyU J F Tietge

Abstract

Are bile acids (BA) and their respective subspecies present in human follicular fluid (FF) and do they relate to embryo quality in modified natural cycle IVF (MNC-IVF)? BA concentrations are 2-fold higher in follicular fluid than in serum and ursodeoxycholic acid (UDCA) derivatives were associated with development of top quality embryos on Day 3 after fertilization. Granulosa cells are capable of synthesizing BA, but a potential correlation with oocyte and embryo quality as well as information on the presence and role of BA subspecies in follicular fluid have yet to be investigated. Between January 2001 and June 2004, follicular fluid and serum samples were collected from 303 patients treated in a single academic centre that was involved in a multicentre cohort study on the effectiveness of MNC-IVF. Material from patients who underwent a first cycle of MNC-IVF was used. Serum was not stored from all patients, and the available material comprised 156 follicular fluid and 116 matching serum samples. Total BA and BA subspecies were measured in follicular fluid and in matching serum by enzymatic fluorimetric assay and liquid chromatography-mass spectrometry, respectively. The association of BA in follicular fluid with oocyte and em...Continue Reading

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Citations

Mar 1, 2016·The Journal of Steroid Biochemistry and Molecular Biology·A Sánchez-GuijoS A Wudy
Jul 10, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Joachim GeyerMartin Bergmann
May 24, 2017·Journal of Lipid Research·Aafke W F JanssenSander Kersten
Mar 17, 2018·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisMarialena Trivella
May 24, 2017·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisDennis Vaidakis
Nov 20, 2018·The Journal of Reproduction and Development·Kentaro TakaeIkuo Tomioka
Sep 8, 2019·Scientific Reports·Ruxandra A NagyUwe J F Tietge
Jun 7, 2019·Hepatology Communications·Aafke P A van MontfoortUwe J F Tietge
Nov 13, 2019·Veterinary Medicine and Science·Carina BlaschkaChristine Wrenzycki
Aug 2, 2019·The American Journal of Pathology·Ruxandra A NagyUwe J F Tietge
Jan 30, 2021·BMC Veterinary Research·Natsumi FuneshimaKoumei Shirasuna

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