Presence of cannabinoid binding sites in the brain from early postnatal ages

Neuroreport
F Rodríguez de FonsecaJ Fernández-Ruiz

Abstract

The present study demonstrates the presence of cannabinoid receptors in the brain from early postnatal ages. Specific and saturable binding was observed in the forebrain and remaining brain from early postnatal ages (2 and 5 days after birth). Female neonate forebrain exhibited a higher receptor density at 2 days after birth than males, but this trend was inverted at 5 days. From postnatal day 10, the receptors could be measured in more defined brain areas, i.e. the striatum, limbic forebrain and ventral mesencephalon. The ontogeny of the receptors in these three areas was relatively similar, exhibiting a progressive increase which maximised on days 30 or 40 and then subsequently decreased to adult values. Subtle sexual dimorphism was found in the striatum and ventral mesencephalon but not the limbic forebrain.

Citations

Nov 1, 1995·Psychopharmacology·M NavarroF R de Fonseca
Apr 1, 1997·Journal of Molecular Neuroscience : MN·M L HernándezJ J Fernández-Ruiz
Jan 11, 2007·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
Dec 7, 2007·Psychopharmacology·Viviana Trezza, Louk J M J Vanderschuren
Jul 25, 2009·Psychopharmacology·Emilio Fernandez-EspejoFernando Rodriguez de Fonseca
Feb 23, 2013·Cell and Tissue Research·Miriam Schneider
Oct 10, 1996·European Journal of Pharmacology·I S McGregorR E Brown
Aug 20, 1996·Brain Research. Developmental Brain Research·E Fride, R Mechoulam
Feb 1, 1996·Psychoneuroendocrinology·E Fride, R Mechoulam
Jan 1, 1995·Neurotoxicology and Teratology·R C BelueD E Hutchings
Aug 21, 2013·Neuropharmacology·Yasmin L HurdDidier Jutras-Aswad
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Liana FattoreWalter Fratta
Feb 6, 2003·European Journal of Pharmacology·Ester FrideRaphael Mechoulam
Aug 26, 1999·Life Sciences·J J Fernández-RuizJ A Ramos
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Jul 13, 2001·Pharmacology & Therapeutics·A C Porter, C C Felder
Jan 1, 1997·Pharmacology & Therapeutics·R G Pertwee
Jul 9, 2002·Brain Research. Developmental Brain Research·Eva M RomeroM Paz Viveros
Jan 13, 2000·Trends in Neurosciences·J Fernández-RuizJ A Ramos
May 17, 2002·Progress in Neurobiology·Emmanuel S OnaiviGeorge R Uhl
Jun 26, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lydie J MorelValérie Daugé
Jul 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Colm M P O'TuathaighJohn L Waddington
Dec 14, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Miriam Schneider, Michael Koch
Jun 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alejandro Higuera-MatasEmilio Ambrosio
Nov 9, 2010·Journal of Psychoactive Drugs·Alecia Dager SchweinsburgSusan F Tapert
Sep 1, 2007·Behavioural Pharmacology·Young May ChaHarry Scott Swartzwelder
Dec 19, 2006·The Journal of Pharmacology and Experimental Therapeutics·Jenny L WileyM Jerry Wright
Jul 30, 2010·The Journal of Pharmacology and Experimental Therapeutics·Nicole L T MooreCynthia M Kuhn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.