Presence of chronic kidney disease and subsequent changes of left ventricular geometry over 4 years in an apparently healthy population aged 60 and older

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Ya-Ting LeeSheng-Hsiung Sheu

Abstract

Chronic kidney disease (CKD) is associated with increased cardiovascular (CV) risk. Left ventricular geometry (LVG) is a predictor for CV events. However, the influence of CKD on LVG changes in the elderly remains unclear. In this study, we performed echocardiography to evaluate LVG at baseline and at 2 and 4 years after baseline in 120 apparently healthy elderly Chinese who were recruited from a screening of 1,500 individuals. No subjects had a history of organic heart disease or chronic medication. CKD was defined as a glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2, as calculated using the Modification of Diet in Renal Disease (MDRD) study equation. The mean age was 71.5 +/- 3.9 years (range: 60-81 years). The prevalences of CKD, concentric remodeling, eccentric hypertrophy and concentric hypertrophy were significantly increased after 4 years (all p < or = 0.033). The LVG changes were only significant in subjects with CKD at baseline (p = 0.039). If we stratified subjects into those with favorable (normal and concentric remodeling) and those with unfavorable LVG (eccentric hypertrophy and concentric hypertrophy), the presence of CKD was an independent predictor for unfavorable LVG after 4 years both in univar...Continue Reading

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Citations

Aug 23, 2012·Clinical Cardiology·David LeibowitzJochanan Stessman
Jun 28, 2015·Therapeutic Advances in Cardiovascular Disease·Greicy Mara Mengue Feniman-De-StefanoLuis Cuadrado Martin
Apr 29, 2016·Therapeutic Advances in Cardiovascular Disease·Greicy Mara Mengue Feniman De StefanoLuis Cuadrado Martin

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