Presence of dendritic cells, T lymphocytes, macrophages, B lymphocytes and glandular tissue in the human fetal larynx

Acta Oto-laryngologica
C DietrichW J Mann

Abstract

The laryngeal mucosa starts to be exposed to infectious agents immediately after birth. The course of laryngeal infections in young children differs significantly from that in adults. The first line of defense encountered by an inhaled infectious agent is the mucosa-associated immune system, which includes immunocompetent cells and secretory components. The cellular elements are partially organized in a typical morphological pattern known as mucosa-associated lymphoid tissue (MALT). Differences in the ability of young children and adults to react to a laryngeal infection raise the questions of whether and to what extent immunocompetent cells are already present in the larynx at birth. These questions were investigated in this study. Dendritic cells, T lymphocytes, B lymphocytes, macrophages and glands were examined and detected in an (immuno-)histological study of 8 fetal larynges (14th-22nd week of gestation). Immunocompetent cells and glands were present mainly in the epi- and subglottic regions and ventricular folds, whereas the glottis was largely spared. The pattern of distribution was scattered and no organized MALT was seen. Essential cell populations of a mucosa-associated immune system for the initiation of an immune r...Continue Reading

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Citations

Jan 9, 2009·Mucosal Immunology·S L ThibeaultM A Birchall
Jan 7, 2010·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Monique E De PaepeQuanfu Mao
Oct 30, 2012·Pathology, Research and Practice·Renata Calciolari Rossi e SilvaVicente de Paula Antunes Teixeira
Jul 29, 2008·Brazilian Journal of Otorhinolaryngology·Janaínna Grazielle Pacheco OlegárioEumenia Costa da Cunha Castro
Jan 3, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Louisa E N ReesMartin A Birchall
Sep 23, 2016·The Laryngoscope·Marie E JettéSusan L Thibeault
Mar 1, 2016·Perspectives of the ASHA Special Interest Groups·Marie Jetté

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