Presence of dynorphin-like immunoreactivity in pheochromocytomas

The Journal of Clinical Endocrinology and Metabolism
T YoshimasaH Imura

Abstract

Using a highly specific and sensitive radioimmunoassay for dynorphin(1-13), dynorphin-like immunoreactivity (dynorphin-LI) was detected in two extramedullary pheochromocytomas and a medullary pheochromocytoma. The contents of dynorphin-LI of two extramedullary and a medullary tumors were 9.2, 2.2, and 34.0 pmole/g, respectively. Gel chromatographic studies of tumor extracts on Sephadex G-50 revealed a peak of dynorphin-LI eluting at the same position as dynorphin-LI contaminated in porcine ACTH extract (Sigma) and another portion of dynorphin-LI eluting in a range of molecular weights larger than that of dynorphin-LI in porcine ACTH extract. These results indicate the presence of dynorphin and possibly its precursor peptide(s) in pheochromocytoma.

Citations

Apr 1, 1982·Irish Journal of Medical Science·L TrümperD Powell
Mar 1, 1984·Regulatory Peptides·T A HowlettL H Rees
Jul 29, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·K NakaoK Takaya
Mar 1, 1982·The Journal of Clinical Investigation·T YoshimasaH Imura
Aug 7, 2003·Endothelium : Journal of Endothelial Cell Research·Alevtina ZharikovaLaszlo Prokai
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·R J ParmerD T O'Connor
Jan 1, 1988·Progress in Histochemistry and Cytochemistry·C Heym, W Kummer

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