PMID: 6112530May 30, 1981Paper

Presence of elevated antibody titres to Epstein-Barr virus before Hodgkin's disease

Lancet
A S Evans, G W Comstock

Abstract

Sera taken 12 and 21 months before the diagnosis of Hodgkin's disease in two patients showed higher antibody levels to several Epstein-Barr-virus (EBV) antigens than did sera from eight matched controls. In one case the titres of all EB antibodies except that to nuclear antigen were raised in a serum sample obtained 45 months after the diagnosis was made. Antibody levels to herpes simplex, cytomegalovirus, and varicella zoster viruses were normal in both cases. A third patient with histiocytic lymphoma had normal EBV and other herpes antibody titres in a serum sample taken 40 months before diagnosis.

Citations

Dec 1, 1993·Postgraduate Medical Journal·C BellasC Cuesta
Oct 1, 1996·Leukemia & Lymphoma·A S DouglasD Reid
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F L Black
Aug 15, 1984·International Journal of Cancer. Journal International Du Cancer·A S Evans, N M Gutensohn
May 15, 1990·International Journal of Cancer. Journal International Du Cancer·D A ClarkD E Onions
Mar 16, 1989·The New England Journal of Medicine·N MuellerJ Vogelman
Mar 15, 1982·International Journal of Cancer. Journal International Du Cancer·P H LevineM Mestre
Sep 30, 1991·International Journal of Cancer. Journal International Du Cancer·N MuellerJ Vogelman

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