Presence of ethanol-sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens

The Journal of Physiology
B FörsteraLuis G Aguayo

Abstract

The nucleus accumbens (nAc) is involved in addiction-related behaviour caused by several drugs of abuse, including alcohol. Glycine receptors (GlyRs) are potentiated by ethanol and they have been implicated in the regulation of accumbal dopamine levels. We investigated the presence of GlyR subunits in nAc and their modulation by ethanol in medium spiny neurons (MSNs) of the mouse nAc. We found that the GlyR α1 subunit is preferentially expressed in nAc and is potentiated by ethanol. Our study shows that GlyR α1 in nAc is a new target for development of novel pharmacological tools for behavioural intervention in drug abuse. Alcohol abuse causes major social, economic and health-related problems worldwide. Alcohol, like other drugs of abuse, increases levels of dopamine in the nucleus accumbens (nAc), facilitating behavioural reinforcement and substance abuse. Previous studies suggested that glycine receptors (GlyRs) are involved in the regulation of accumbal dopamine levels. Here, we investigated the presence of GlyRs in accumbal dopamine receptor medium spiny neurons (MSNs) of C57BL/6J mice, analysing mRNA expression levels and immunoreactivity of GlyR subunits, as well as ethanol sensitivity. We found that GlyR α1 subunits are...Continue Reading

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Citations

Aug 10, 2017·Cellular and Molecular Life Sciences : CMLS·Hanns Ulrich ZeilhoferGonzalo E Yévenes
May 2, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S GallegosL G Aguayo
May 22, 2020·British Journal of Pharmacology·Loreto San MartinLuis G Aguayo
Jul 28, 2018·Frontiers in Molecular Neuroscience·Braulio MuñozLuis G Aguayo
Mar 18, 2020·Scientific Reports·Gustavo Moraga-CidGonzalo E Yévenes
Dec 23, 2020·Journal of Neural Transmission·Yasmin OlssonBo Söderpalm
Aug 20, 2021·Aging Cell·Eduardo J Fernandez-PerezLuis G Aguayo
Nov 9, 2021·Frontiers in Molecular Neuroscience·Loreto S San MartinLuis G Aguayo

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