PMID: 6539209Apr 1, 1984Paper

Presence of fibroblast-transforming genes in normal DNA of several mouse and rat strains

European Journal of Cancer & Clinical Oncology
P Bentvelzen

Abstract

Cellular DNA of the inbred mouse strains BALB/c, C3Hf, C57BL, CBA, DBAf , GRS and ND2 and the inbred rat strains BN, SD and WAG was shown to oncogenically transform murine fibroblasts of the continuous cell line BALB/3T3. Subcutaneous inoculation of transformed cells into BALB/c mice led to the rapid development of sarcomas. For transformation the DNA had to be fragmented to a size smaller than 23 kilobase pairs (kbp), with a lower limit of 6.5 kbp. No transforming virus could be rescued from the transformed lines by infection with a murine leukemia virus.

References

Oct 1, 1968·Journal of Cellular Physiology·S A Aaronson, G J Todaro
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C J DerG M Cooper
Aug 27, 1982·Science·G M Cooper
Nov 11, 1982·Nature·C J TabinE H Chang
Sep 25, 1980·Nature·V Krump-Konvalinkova, K J van den Berg

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Citations

Jan 1, 1991·Radiation and Environmental Biophysics·P van KlaverenP Bentvelzen

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