Presence of free radicals in intracameral agents commonly used during cataract surgery

The British Journal of Ophthalmology
David LockingtonKanna Ramaesh

Abstract

Free radicals are known to cause cellular damage and are present in ophthalmic preparations. Corneal defence mechanisms are bypassed in intra-ocular surgery. We evaluated commonly used intracameral agents to ascertain the presence of free radicals and investigate the possibility of anterior segment and endothelial toxicity. Samples of 19 commonly used intracameral preparations were analysed for total free radical presence on an Instrument Laboratory IL600 using a Randox Kit for Total Antioxidant Status (RANDOX Laboratories Ltd, Crumlin, UK). Free radical concentrations for the 19 intracameral agents ranged from 0 to 3.59 mmol/l, with median value of 0.34 mmol/l (mean value 0.933±1.19 mmol/l). Phenylephrine had the highest presence of free radicals, which were considerably higher than those for 0.5% hydrogen peroxide at all tested dilutions. Other notable results included cefuroxime (0.61 mmol/l), 2% undiluted lidocaine (0.34 mmol/l) and bevacizumab (0.59 mmol/l). The results indicate that free radicals are present in intracameral surgical agents and some are in the order of 0.5% hydrogen peroxide. The risks of endothelial damage must be considered when using multiple intracameral preparations in complicated cataract surgery. Fr...Continue Reading

Citations

Dec 19, 2012·Middle East African Journal of Ophthalmology·Gwyn S WilliamsChristopher P R Williams
Oct 7, 2014·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·David LockingtonKanna Ramaesh
Jun 26, 2014·Cutaneous and Ocular Toxicology·Ali AkalNurten Aksoy
Oct 23, 2016·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Murat AslankurtOsman Dursun
Mar 7, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Murat AslankurtOsman Çekiç
Nov 13, 2014·Current Opinion in Ophthalmology·Hassan HashemiMehrdad Mohammadpour
Oct 26, 2018·BMC Ophthalmology·Choul Yong ParkRoy S Chuck
Nov 15, 2011·Current Opinion in Ophthalmology·Parisa TaravatiRussell N Van Gelder
Jan 13, 2021·Journal français d'ophtalmologie·C-H KochA-S Gauthier

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