PMID: 8973730Nov 1, 1996Paper

Presence of human papillomavirus in squamous cell laryngeal carcinomas. A study of thirty-nine cases using polymerase chain reaction and in situ hybridization

Acta Oto-laryngologica
E S LieR Holm

Abstract

Human papillomavirus (HPV) has a well-established association with benign and malignant cervical tumours as well as with laryngeal papillomas, while its association with laryngeal carcinomas is still controversial. We have examined 39 squamous cell carcinomas of the larynx for HPV using PCR with three consensus primers (Cp, My 09/11 and Gp 5+/6+). Specimens positive for consensus primers were examined with specific PCR primers for HPV 6, 11, 16, 18, 31, 33 and 35 and with in situ hybridization (ISH). Three samples (8%) were found HPV positive for two or three consensus primers. One case was confirmed to be HPV 16 with both PCR and ISH. The findings of both a punctate and diffuse signal with the use of ISH indicated HPV to be in both integrated and episomal form. For the other two HPV positive specimens, the examination indicated a type related to HPV 6/11, but it could not be determined with certainty. This study strongly indicates that HPV 16 is associated with some squamous cell laryngeal carcinomas. The possibility of association with other HPV types or mutants of these needs further investigation.

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Citations

Mar 6, 2012·Cancer Letters·Maria J WorshamVanessa G Schweitzer
Jan 13, 2011·Oncology Reports·Josena K StephenMaria J Worsham
Jul 17, 2012·Otolaryngologic Clinics of North America·Andrew W Joseph, Gypsyamber D'Souza
Feb 15, 2008·Auris, Nasus, Larynx·Naoki ShimizuRyuji Okamura
Apr 9, 2013·PloS One·P Sivaramakrishna RachakondaRajiv Kumar
Sep 11, 2016·Journal of Voice : Official Journal of the Voice Foundation·Massimo FusconiMarco de Vincentiis
Nov 23, 2000·The Annals of Otology, Rhinology, and Laryngology·E M SmithT H Haugen
Sep 25, 2001·The Laryngoscope·H H Dedo, K C Yu
Aug 23, 2007·Acta Oto-laryngologica·Mariela C Torrente, Jose M Ojeda
Mar 1, 2002·Journal of Surgical Oncology·Sajini Elizabeth JacobM Radhakrishna Pillai
Sep 15, 2005·Acta Oto-laryngologica·Mariela C TorrenteJose M Ojeda
Apr 25, 2015·Vestnik otorinolaringologii·O V CheremisinaO Yu Dvorayninova
May 24, 2011·International Journal of Head and Neck Surgery·Josena K StephenMaria J Worsham

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