PMID: 9159407Jan 1, 1997Paper

Presence of IgM antibodies which sensitize HIV-1-infected cells to cytolysis by homologous complement in long-term survivors of HIV infection

Microbiology and Immunology
N OkadaH Okada

Abstract

Although human cells are resistant to homologous human complement due to the presence of species-specific membrane inhibitors, a naturally occurring IgM antibody which recognizes an asialo-oligosaccharide can sensitize HIV-1-infected cells for complement-mediated cytolysis. Therefore, we investigated whether long-term survivors of HIV-1 infection harbor such antibodies in their sera. Thirty of 31 sera from HIV-1 seropositive hemophilia patients who have survived HIV-1 infection 10 years or more showed appreciable cytolytic activity, while only 2 sera of 10 seropositive patients presumed to have been infected with HIV-1 (due to sexual contact) more recently showed cytolytic activity. On the other hand, only 7 out of 43 sera from seronegative hemophilia patients showed cytolytic activity. Immunofluorescence staining for IgM on HIV-1-infected cells essentially correlated with the cytolytic capacity of the sera. Therefore, naturally occurring IgM antibodies and/or generated IgM antibodies reactive with the HIV-1-infected cells in patients might have been responsible for long-term survival due to complement-mediated immune cytolysis which may, in conjunction with cytotoxic T lymphocytes, synergistically suppress the infected cells i...Continue Reading

References

Sep 1, 1991·Immunology Today·P J Lachmann
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M M LedermanM E Medof
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J L ColeJ P Atkinson

❮ Previous
Next ❯

Citations

Oct 19, 1999·Microbiology and Immunology·N Okada, H Okada
Jul 20, 2010·Immunotherapy·Anastas PashovThomas Kieber-Emmons

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.