PMID: 8590458Apr 1, 1995Paper

Presence of interleukin-10 transcripts in human pituitary and hypothalamus

Cellular and Molecular Neurobiology
Peter L RadyThomas K Hughes

Abstract

1. Recent data have shown that interleukin-10 (IL-10) is expressed and acts in mouse pituitary tumor cells and freshly isolated mouse pituitaries. 2. In this study, we show that poly(A+) RNA derived from normal human pituitary and hypothalamus expresses IL-10 message. 3. The majority of transcripts was likely from the pituitary and hypothalamus, and not from lymphocytes in the pituitary and hypothalamic vasculature, since both IL-10 and interferon-gamma mRNA levels, compared to equivalent amounts of RNA from peripheral blood lymphocytes, were much lower. 4. These results indicate that IL-10 may function in human neuroendocrine process as it does in the murine system, thus serving as an important signal molecule for bidirectional communication between the neuroendocrine and the immune systems.

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Citations

Feb 14, 2007·Cellular and Molecular Neurobiology·Huolin TuThomas K Hughes
Nov 22, 2000·Brain Research. Brain Research Reviews·V PrevotJ Beauvillain
Jun 12, 2003·Journal of Neuroimmunology·Huolin TuThomas K Hughes
Mar 1, 2000·Journal of Neuroimmunology·E M SmithT K Hughes
Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J B Tatro
Jan 26, 1999·Annals of the New York Academy of Sciences·L R LeonM J Kluger
Nov 26, 2009·Cardiovascular Psychiatry and Neurology·Susana RoqueNuno Sousa
Jul 1, 1998·International Reviews of Immunology·P Stordeur, M Goldman
Jan 14, 1999·The American Journal of Physiology·L R LeonM J Kluger
Jul 27, 2005·Biochemical Society Transactions·M E MooreM A Lynch

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