PMID: 2337907Jan 1, 1990Paper

Presence of interleukin-2 in urine of superficial bladder cancer patients after intravesical treatment with bacillus Calmette-Guérin

Cancer Immunology, Immunotherapy : CII
W H de JongE J Ruitenberg

Abstract

Urine samples were obtained from patients with superficial bladder cancer after immunotherapy with bacillus Calmette-Guérin (BCG). The patients were repeatedly (once a week for 6 consecutive weeks) treated with intravesical administration of approximately 5 X 10(8) culturable particles of BCG. Some patients received more than six BCG instillations. The urine samples were investigated for the presence of interleukin-2 (IL-2) in an in vitro bioassay using a murine cytotoxic T cell line (CTTL-16) that shows IL-2-dependent growth. Preliminary experiments indicated the presence of inhibitory factors in the urine. This inhibitory activity was abolished after 24 h dialysis. In a neutralization assay with both polyvalent and monoclonal anti-(human IL-2) antibody it was demonstrated that there was indeed IL-2 in the urine samples. In 8 of 11 patients the presence of IL-2 in the urine was demonstrated. The IL-2 production was directly related to the BCG administration as samples obtained just before the BCG instillation were always negative. In IL-2-positive samples a maximum level of IL-2 was observed between 2 h and 6 h after the BCG instillation. In urine samples obtained 24 h after the BCG IL-2 was not detected. In most patients the ...Continue Reading

References

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Citations

Jul 11, 2012·Advances in Urology·Eric J AskelandYi Luo
Jun 22, 2010·Immunotherapy·Sylvia Adams
Apr 19, 2015·Mathematical Medicine and Biology : a Journal of the IMA·Svetlana Bunimovich-MendrazitskyNatalie Kronik
Jun 2, 2016·Therapeutic Advances in Urology·Akhil MuthigiPiyush K Agarwal
Aug 1, 1996·Tropical Animal Health and Production·S C Bishop, P Cardozo
Jan 1, 1993·Journal of Biomaterials Science. Polymer Edition·G R Llanos, M V Sefton
Sep 19, 2014·Expert Review of Anticancer Therapy·Yonghua WangXinsheng Wang

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