PMID: 8944618Nov 1, 1996Paper

Presence of katG gene in resistant Mycobacterium tuberculosis

Journal of Clinical Pathology
M JaberR Kumar

Abstract

It has been reported recently that isoniazid resistant strains of Mycobacterium tuberculosis have lost the katG gene which encodes the catalase-peroxidase enzyme. A 35 mer oligonucleotide probe specific for the katG gene of M tuberculosis, 3' end-labelled with digoxigenin, was constructed and hybridised with DNA extracted from 26 clinical isolates of M tuberculosis under high stringency conditions. Twenty two of these isolates were resistant to 0.2 microgram/ml isoniazid and 20 to 1.0 microgram/ml isoniazid. Semiquantitative detection of catalase did not show any discrimination between isoniazid sensitive and resistant strains. The katG gene was present in all clinical strains of M tuberculosis. Therefore, complete deletion of the katG gene does not seem to be the mechanism of isoniazid resistance in M tuberculosis strains isolated from patients in India.

References

Oct 1, 1994·Trends in Microbiology·S T Cole
May 1, 1994·The Journal of Infectious Diseases·M AltamiranoJ A Smith
Dec 1, 1995·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M JaberR Kumar

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Citations

Jun 11, 1998·Emerging Infectious Diseases·A RattanN Ahmad
Mar 15, 2015·Journal of Drug Targeting·Sanaul MustafaV Kusum Devi
Mar 13, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Antônio Carlos Moreira Lemos, Eliana Dias Matos
Jun 16, 2021·MSystems·D Aytan-AktugJ J Davis

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