PMID: 9531976Apr 9, 1998Paper

Presence of laminin fragments in cyst fluid from patients with autosomal dominant polycystic kidney disease (ADPKD): role in proliferation of tubular epithelial cells

Biochimica Et Biophysica Acta
M J SladeR G Price

Abstract

Cyst fluid samples obtained from eight patients with autosomal dominant polycystic kidney disease (ADPKD) were analysed for the presence of the basement membrane component laminin and its breakdown products, using ELISA and immunoblotting techniques. Whole laminin was not detected, whereas laminin fragments of 270, 155, 87, 56, and 14 kDa were detected at a mean total value of approximately 0.5 microgram/ml. The laminin fragments were assessed for their effect on cultured normal and ADPKD epithelial cells. Both cell types showed accelerated growth under these conditions. These findings suggest that basement membrane degradative fragments present in cyst fluid may contribute to cystic epithelial cell proliferation and may therefore be important in the pathogenesis of ADPKD.

References

Jun 16, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Macart, L Gerbaut
Jul 29, 1993·The New England Journal of Medicine·P A Gabow

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Citations

May 14, 1999·Pharmaceutical Science & Technology Today·S F Hamm-Alvarez
May 28, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Jian-Rao LuLi Ma
Jul 28, 2006·The Journal of Biological Chemistry·Dominique JolyBertrand Knebelmann
Feb 22, 2001·American Journal of Physiology. Renal Physiology·N ObermüllerR Witzgall
Apr 19, 2008·Journal of Proteome Research·Esmé WaandersJoost P H Drenth
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Ashraf N MalhasRobert G Price

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