Presence of mature sperm in testicular parenchyma of men with nonobstructive azoospermia: prevalence and predictive factors

Urology
J P MulhallR D Oates

Abstract

Hitherto, patients with testicular dysfunction and azoospermia had to resort to adoption, donor sperm insemination, or child-free living. The realization that a proportion of such men harbor spermatozoa in their testicular parenchyma, combined with the ability of intracytoplasmic sperm injection (ICSI) to effect pregnancy with single sperm, has prompted male infertility clinicians to explore testicular sperm extraction (TESE) in this patient population. We sought to investigate the likelihood of finding spermatozoa during TESE from men presenting with nonobstructive azoospermia and to define if any factors existed that were predictive of eventual sperm presence or absence. Thirty patients with nonobstructive azoospermia underwent TESE and simultaneous formal testis biopsy, cytologic analysis, and wet preparation analysis. Tissue obtained from TESE was analyzed according to a rigorous protocol, followed by exhaustive searching by trained embryologists. Twenty-one patients (70%) had spermatozoa found on testicular tissue analysis. Neither patient age nor follicle-stimulating hormone (FSH) level was predictive of the ability to find sperm. With regard to histologic pattern, 50% of men with Sertoli cell-only, 75% of patients with m...Continue Reading

References

Jan 1, 1980·Fertility and Sterility·T J ColganP H Klotz
Nov 13, 1993·Lancet·R SchoysmanD Schoysman
Oct 1, 1995·Journal of Assisted Reproduction and Genetics·A ObrucaG Lunglmayr

❮ Previous
Next ❯

Citations

Aug 7, 2002·Current Oncology Reports·Simon J Howell, Stephen M Shalet
Jun 27, 2002·Current Urology Reports·P T Chan, P N Schlegel
Sep 24, 2004·Gynécologie, obstétrique & fertilité·V VernaeveH Tournaye
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·S Howell, S Shalet
May 22, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·E IammarroneJ G Grudzinskas
Jan 25, 2011·Asian Journal of Andrology·Monika E Beliveau, Paul J Turek
Feb 14, 2006·Nature Clinical Practice. Urology·Paul J Turek
Nov 29, 2011·Asian Journal of Andrology·Tomomoto Ishikawa
Oct 9, 2007·Current Opinion in Urology·Moshe WaldCraig S Niederberger
Nov 30, 2013·The Urologic Clinics of North America·Boback M Berookhim, Peter N Schlegel
Jan 5, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M Garcia-LegnameJ Hubert
Oct 16, 2012·Actas urologicas españolas·C R BonarribaP Pizá
Mar 24, 2009·Fertility and Sterility·Angelo CarpiJeffrey Mechanick
Apr 22, 2008·The Urologic Clinics of North America·Stephanie E Harris, Jay I Sandlow
Dec 19, 2006·Fertility and Sterility·Ralf HerwigGermar-Michael Pinggera
Sep 21, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Akira Tsujimura
Apr 11, 2017·Fertility and Sterility·Natali Schachter-SafraiIris Har-Vardi
Sep 7, 2006·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Shai Shefi, Paul J Turek
Dec 18, 2001·The Journal of Urology·Richard A SchoorLawrence S Ross
Aug 25, 2000·Obstetrics and Gynecology Clinics of North America·A SpitzL I Lipshultz
Mar 26, 2014·Urologia·Massimiliano TimpanoBruno Frea
Dec 4, 2013·Nature Reviews. Urology·Daniel H Shin, Paul J Turek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.